ARSI
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Official Full Name
arylsulfatase family, member I
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Overview
Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans,;and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of;macromolecules (Sardiello et al., 2005 (PubMed 16174644)). -
Synonyms
ARSI; arylsulfatase family, member I; arylsulfatase I; FLJ16069; ASI;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARSI-962H | Recombinant Human ARSI | Mammalian Cell | His | ||
Human | ARSI-9903H | Recombinant Human ARSI, His-tagged | E.coli | His | 220-569a.a. | |
Human | ARSI-39HCL | Recombinant Human ARSI lysate | HEK293 | N/A | ||
Human | ARSI-2503H | Recombinant Human ARSI Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | ARSI-2503H-B | Recombinant Human ARSI Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ARSI-1984M | Recombinant Mouse ARSI Protein | Mammalian Cell | His | ||
Mouse | ARSI-760M | Recombinant Mouse ARSI Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARSI-760M-B | Recombinant Mouse ARSI Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARSI-807R | Recombinant Rat ARSI Protein | Mammalian Cell | His | ||
Rat | ARSI-463R-B | Recombinant Rat ARSI Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARSI-463R | Recombinant Rat ARSI Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
ARSI involved in several pathways and played different roles in them. We selected most pathways ARSI participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Gamma carboxylation, hypusine formation and arylsulfatase activation | ARSF;FURINA;EIF5A2;SUMF2;ARSK;PROZ;DHPS;DOHH;OTOP2 |
Glycosphingolipid metabolism | ARSE;ARSJ;GLTPD1;ARSF;ARSK;ARSI;SUMF2;CPTP;GLB1L |
Metabolism | ADHFE1;BCKDK;SULT1ST6;ACOT13;TIAM2;ELA2L;NAT2;TYMP;C2orf56 |
Metabolism of lipids and lipoproteins | AKR1C2;MED21;CYP2N13;PTPMT1;FA2H;BRSK2;APOA4B.2;ECI1;ARSD |
Metabolism of proteins | CPN1;IGFBP1A;GPR116;CBX8;CTDSP2;EXOC1;IGFBP6B;MPDU1B;CPB1 |
Post-translational protein modification | GCNT3;SLC35A1;TRAPPC6BL;MPDU1;C8orf84;PHC3;TRAPPC2L;TFG;EIF5A2 |
Sphingolipid metabolism | NEU3.2;CERS1;SMPD5;ENPP7;CERS5;ARSH;CERK;ASAH1;OSBP |
The activation of arylsulfatases | SUMF2;ARSJ;ARSK;ARSI;ARSF;ARSH |
ARSI has several biochemical functions, for example, arylsulfatase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSI itself. We selected most functions ARSI had, and list some proteins which have the same functions with ARSI. You can find most of the proteins on our site.
Function | Related Protein |
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arylsulfatase activity | ARSG;ARSI;ARSB;SULF1;ARSF;ARSK;ARSJ;SULF2;ARSE |
metal ion binding | POLL;MOXD2;RNASEL;DOHH;SALL3;A3GALT2;TENC1;ZNF79;ZFML |
protein binding | HYI;L3MBTL2;HBP1;FAM124B;GRASP;UBE2C;MYO1C;NDNL2;CNOT3 |
ARSI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSI here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSI.
KRT40
- Q&As
- Reviews
Q&As (10)
Ask a questionAutosomal recessive multiple sulfatase deficiency is a genetic disorder that results from inherited mutations, so it cannot be prevented at present. However, genetic counseling and testing can help identify carrier status in individuals and guide family planning decisions.
Yes, research is ongoing to better understand the underlying mechanisms of autosomal recessive multiple sulfatase deficiency and to develop potential treatments. This includes studying enzyme replacement therapy, gene therapy, and other innovative approaches.
Diagnosis of autosomal recessive multiple sulfatase deficiency is typically confirmed through clinical evaluation, examination of symptoms, and genetic testing to identify ARSI gene mutations.
The ARSI protein acts on various molecules, including glycosaminoglycans (GAGs) such as heparan sulfate, chondroitin sulfate, and dermatan sulfate. It also acts on sulfated steroids like estrone sulfate and dehydroepiandrosterone sulfate.
Symptoms of autosomal recessive multiple sulfatase deficiency can vary but may include developmental delays, intellectual disability, skeletal abnormalities, skin abnormalities, and in severe cases, organ dysfunction.
Autosomal recessive multiple sulfatase deficiency is a rare and severe disorder, and individuals with the condition typically experience significant health challenges. In most cases, affected individuals may have difficulty having children due to their overall health condition and associated complications. However, family planning decisions should be discussed with healthcare professionals based on individual circumstances.
When the ARSI protein is deficient or non-functional, the removal of sulfate groups from molecules is impaired. This leads to the accumulation of sulfated compounds within cells, disrupting their normal function and potentially causing downstream effects on various biological processes.
There is currently no cure for autosomal recessive multiple sulfatase deficiency, and treatment primarily focuses on managing symptoms and providing supportive care. This may include physical therapy, occupational therapy, and medical interventions to address specific symptoms or complications.
Deficiency or non-functioning of the ARSI protein can result in a condition known as autosomal recessive multiple sulfatase deficiency (MSD). This condition leads to the accumulation of sulfated molecules within cells, causing a variety of symptoms throughout the body.
Yes, there are other proteins and enzymes involved in sulfate metabolism. For example, the ARSJ protein (Arylsulfatase J) is another enzyme that plays a role in removing sulfate groups. Additionally, proteins involved in sulfate transport, such as SLC13A1 and SLC26A2, are important for maintaining sulfate balance within cells.
Customer Reviews (3)
Write a reviewWhether I am studying protein-protein interactions, investigating cellular pathways, or examining protein folding dynamics, the ARSI protein consistently delivers exceptional performance and precise outcomes.
The versatility of the ARSI protein is truly remarkable, as it can be employed across a wide range of applications in my research.
The excellent technical support provided by the manufacturer can solve my problem.
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