ARSK
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Official Full Name
arylsulfatase family, member K
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Overview
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans,;and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of;macromolecules (Sardiello et al., 2005 (PubMed 16174644)). -
Synonyms
ARSK; arylsulfatase family, member K; arylsulfatase K; DKFZp313G1735; TSULF; arylsulfatase family member K; Arylsulfatase K precursor; ASK; OTTHUMP00000149978; Telethon sulfatase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARSK-868H | Recombinant Human ARSK protein, GST-tagged | Wheat Germ | GST | ||
Human | ARSK-8673HCL | Recombinant Human ARSK 293 Cell Lysate | HEK293 | N/A | ||
Human | ARSK-1386HF | Recombinant Full Length Human ARSK Protein, GST-tagged | In Vitro Cell Free System | GST | 536 amino acids | |
Mouse | ARSK-1986M | Recombinant Mouse ARSK Protein | Mammalian Cell | His | ||
Mouse | ARSK-761M | Recombinant Mouse ARSK Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARSK-761M-B | Recombinant Mouse ARSK Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARSK-808R | Recombinant Rat ARSK Protein | Mammalian Cell | His | ||
Rat | ARSK-464R-B | Recombinant Rat ARSK Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARSK-464R | Recombinant Rat ARSK Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | ARSK-4616Z | Recombinant Zebrafish ARSK | Mammalian Cell | His | ||
Chicken | ARSK-3066C | Recombinant Chicken ARSK | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARSK involved in several pathways and played different roles in them. We selected most pathways ARSK participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Gamma carboxylation, hypusine formation and arylsulfatase activation | DPH5;EEF2;DNAJC24;F9B;FURINB;ATPBD4;ARSD;ARSE;SUMF2 |
Glycosphingolipid metabolism | ARSD;GLTPD1;GLTP;NEU4;ARSK;ARSE;SUMF2;ARSJ;ARSH |
Metabolism | AKAP5;SLC25A15;CYP2U1;ELOVL1A;PDK4;SACM1LA;TM9SF1;IP6K3;AQP1A.2 |
Metabolism of lipids and lipoproteins | ACOT13;SLC25A1;MED21;CYP27B1;PIK3R6;GRHL1;ACOT11A;CETP;TPTE |
Metabolism of proteins | TIMM8A;MIA3;ALG10B;BET1;EIF2B1;WIPI1;GPR119;PAPPAB;PFDN4 |
Post-translational protein modification | MAGT1;DPAGT1;B3GNT6;GNE;TRAPPC2L;ARSE;STT3A;PPP6R3;MUC5AC |
Sphingolipid metabolism | LASS5;B4GALT6;SUMF2;NEU3.3;GALCB;SMPD5;VAPB;SPTLC2;PPM1LB |
The activation of arylsulfatases | ARSJ;ARSF;ARSH;ARSK;ARSI;SUMF2 |
ARSK has several biochemical functions, for example, arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSK itself. We selected most functions ARSK had, and list some proteins which have the same functions with ARSK. You can find most of the proteins on our site.
Function | Related Protein |
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arylsulfatase activity | SULF2;ARSD;SULF1;ARSG;ARSH;ARSE;ARSA;ARSB;ARSF |
metal ion binding | RPS27A;RIMS1;ASAP1;ITGA7;NAIP7;CISD2;CCDC71L;TP63;MLPH |
ARSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSK here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSK.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe ARSK protein is known to hydrolyze a specific class of sulfates known as sulfatides. Sulfatides are a type of glycosphingolipid found in various tissues and cells, particularly in the nervous system. ARSK catalyzes the breakdown of sulfatides into sulfate ions and ceramide.
Yes, genetic variations or mutations in the ARSK gene have been reported in individuals with ARSK-related disorders. These variations can interfere with the proper functioning of the enzyme, leading to impaired sulfate metabolism and the associated clinical symptoms.
Deficiency or dysfunction of the ARSK protein can lead to a rare genetic disorder called ARSK-related disorder. This condition is characterized by the accumulation of sulfatides, a type of lipid, in various organs and tissues, leading to tissue damage and dysfunction.
Some studies have suggested that ARSK dysfunction and subsequent sulfatide accumulation may contribute to the pathogenesis of certain neurodegenerative diseases, such as multiple sclerosis and metachromatic leukodystrophy. The deposition of sulfatides in neural tissues may disrupt myelin integrity and impair nerve conduction.
Currently, there are no specific treatments or therapies available for ARSK-related disorders. Management typically involves symptomatic and supportive care to address the specific symptoms and complications that arise due to sulfatide accumulation.
Yes, genetic testing can be used to diagnose ARSK-related disorders. By sequencing the ARSK gene and identifying disease-causing variations or mutations, a definitive diagnosis can be made. Genetic counseling may also be offered to affected individuals and their families.
The long-term effects of ARSK dysfunction may vary depending on the severity and specific manifestations of the disorder. Sulfatide accumulation can lead to damage in various organs, including the brain, liver, and kidneys, resulting in neurological, hepatic, or renal impairments over time.
Currently, there is limited research on whether the ARSK protein is implicated in other diseases or conditions. Further studies are needed to determine if it plays a role in other aspects of sulfate metabolism or if dysregulation of ARSK is associated with other disorders.
At present, no specific inhibitors or activators of the ARSK protein have been identified. The development of small molecules or compounds that can modulate ARSK activity could hold potential for future therapeutic interventions, but more research is needed in this area.
The regulation of the ARSK protein is not fully understood. It is likely controlled at the transcriptional level, where the expression of the ARSK gene is influenced by various regulatory factors. Additionally, post-translational modifications and protein-protein interactions may also participate in the regulation of ARSK activity.
Customer Reviews (3)
Write a reviewWhen used in Western Blotting experiments, the ARSK protein consistently generates clear and distinct protein bands.
It has been invaluable in protein electron microscopy structure analysis, facilitating detailed investigations and yielding valuable insights.
This exceptional clarity allows for accurate quantification and analysis, contributing to the overall success of my research endeavors.
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