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GCNT1

Official Full Name

glucosaminyl (N-acetyl) transferase 1, core 2
Overview

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms

GCNT1; glucosaminyl (N-acetyl) transferase 1, core 2; glucosaminyl (N acetyl) transferase 1, core 2 (beta 1,6 N acetylglucosaminyltransferase) , NACGT2; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; beta 1; 3 galact;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian cells
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GCNT1-714H	Active Recombinant Human GCNT1, His-tagged	Mammalian cells	His		Inquiry
Human	GCNT1-617H	Active Recombinant Human Glucosaminyl (N-acetyl) Transferase 1, Core 2, His-tagged	Mammalian cells	His		Inquiry
Human	GCNT1-13198H	Recombinant Human GCNT1, GST-tagged	E.coli	GST	41-428a.a.	$319 / 25ug
Human	GCNT1-27452TH	Recombinant Human GCNT1	Wheat Germ	N/A	428 amino acids	Inquiry
Human	GCNT1-5980HCL	Recombinant Human GCNT1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GCNT1-4804H	Recombinant Human GCNT1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GCNT1-5185HF	Recombinant Full Length Human GCNT1 Protein, GST-tagged	In Vitro Cell Free System	GST	428 amino acids	Inquiry
Human	GCNT1-3025H	Recombinant Human GCNT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	GCNT1-3025H-B	Recombinant Human GCNT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	GCNT1-195HF	Recombinant Full Length Human GCNT1 Protein	In Vitro Cell Free System		428 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GCNT1 Related Articles

GCNT1 involved in several pathways and played different roles in them. We selected most pathways GCNT1 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mucin type O-Glycan biosynthesis	WBSCR17;GCNT1;C1GALT1C1;C1GALT1;GALNTL2;C1GALT1B;GALNT18A;GALNT2;GALNT5
Metabolic pathways	NNMT;PLD2;SDSL;ATP5J;ATP6V1C1B;mt-Atp8;MAT1A;LIPC;BCAT2

GCNT1 has several biochemical functions, for example, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT1 itself. We selected most functions GCNT1 had, and list some proteins which have the same functions with GCNT1. You can find most of the proteins on our site.

Function	Related Protein
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	GCNT1;GCNT4;GCNT3;GCNT4A
protein binding	CYGB;ROCK2A;POLR1D;PPP2R3A;CCDC24;RCC2;YWHAG;CHMP5;UBE2D3

GCNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT1.

GOLPH3; SEC24D; LAP3; CLTC; HSPA14; RSU1; CCDC80; VPS36; STMN2; CCT7; OSBPL1A; PARVA

Petrosyan, A; Holzapfel, MS; et al. Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-Induced Apoptosis by Modifying Mucin O-Glycan Synthesis. MOLECULAR CANCER RESEARCH 12:1704-1716(2014).

Chen, ZX; Gulzar, ZG; et al. Increased Expression of GCNT1 is Associated With Altered O-glycosylation of PSA, PAP, and MUC1 in Human Prostate Cancers. PROSTATE 74:1059-1067(2014).