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RHOA

  • Official Full Name

    ras homolog family member A

  • Overview

    Ras is the name given to a family of related proteins which is ubiquitously expressed in all cells, . All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
  • Synonyms

    RHOA; ras homolog family member A; ARH12, ARHA, ras homolog gene family, member A; transforming protein RhoA; Rho12; RhoA; RHOH12; h12; oncogene RHO H12; rho cDNA clone 12; Aplysia ras-related homolog 12; small GTP binding protein RhoA; ras homolog gene;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RHOA-33H Active Recombinant Human RHOA protein, His-tagged E.coli His
Human RHOA-179H Active Recombinant Human RHOA, His-tagged E.coli His
Human RHOA-34H Active Recombinant Human RHOA protein, GST-tagged E.coli GST
Human RHOA-3372H Recombinant Human Ras Homolog Gene Family, His-tagged E.coli His
Human RHOA-2290H Recombinant Human RHOA, GST-tagged E.coli GST 1-193aa
Human RHOA-1146H Recombinant Human Ras Homolog Gene Family, Member A, GST-tagged E.coli GST
Human RHOA-1145H Recombinant Human Ras Homolog Gene Family, Member A E.coli N/A
Human RHOA-27379TH Recombinant Human RHOA E.coli N/A
Human RHOA-3975H Recombinant Human RhoA protein(Met1-Leu193), His-tagged Insect Cells N-His Met1-Leu193
Human RHOA-313H Recombinant Human RHOA Mammalian Cell His
Human RHOA-1627H Recombinant Human Ras Homolog Gene Family, Member A, His-tagged E.coli His
Human RHOA-32H Recombinant Human RHOA protein, His-tagged E.coli His
Human RHOA-601HCL Recombinant Human RHOA cell lysate Insect Cell N/A
Human RHOA-1182H Recombinant Human RHOA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RHOA-160H Recombinant Human RHOA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human RHOA-5149H Recombinant Human RHOA protein, GST-tagged E.coli GST 1-191aa
Human RHOA-301418H Recombinant Human RHOA, GST-tagged E.coli GST Asn123-Ala161
Human RHOA-2117HFL Recombinant Full Length Human RHOA Protein, C-Flag-tagged Mammalian cells Flag
Human RHOA-2655H Recombinant Human RHOA Protein, His-tagged E.coli N-His Met1-Cys190
Human RHOA-1888H-B Recombinant Human RHOA Protein Pre-coupled Magnetic Beads HEK293
Human RHOA-1888H Recombinant Human RHOA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rhoa-641M Recombinant Mouse Rhoa Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat RHOA-5035R Recombinant Rat RHOA Protein Mammalian Cell His
Rat RHOA-4694R Recombinant Rat RHOA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RHOA-4694R-B Recombinant Rat RHOA Protein Pre-coupled Magnetic Beads HEK293
Chicken RHOA-6269C Recombinant Chicken RHOA Mammalian Cell His
Kit-0768 RhoA Activation ColorimetricAssay Kit (24 assays) N/A
Kit-0769 RhoA Activation Colorimetric Assay Kit (96 assays) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • RHOA Related Signal Pathway

RHOA involved in several pathways and played different roles in them. We selected most pathways RHOA participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayRAC3;PLCG2;PDGFRB;PIK3CD;RASSF1;FGF2;PLA2G1B;PLA2G5;GNG5
Rap signaling pathwayVAV2;PRKCA;CDH1;RAF1;GNAQ;FGF19;RAP1B;FGF11;LPAR2
cGMP-PKG signaling pathwayPPP1CA;BDKRB2;MAPK3;CREB3L2;AKT1;CALM4;SLC25A31;NPPB;PLCB2
cAMP signaling pathwayVAV3;ACOX1;MAPK3;GRIA3;GRIN2C;CAMK2D;LIPE;PIK3CA;GABBR1
Chemokine signaling pathwayGNG10;RELA;CXCL14;IKBKB;CCL3;PIK3R2;GNG7;PTK2;ELMO1
Sphingolipid signaling pathwayACER1;PLCB1;PRKCZ;SPTLC3;PPP2R5A;PPP2R1B;MAPK11;PLCB2;PDPK1
Phospholipase D signaling pathwayHRAS;SPHK1;GNAS;INS2;MAP2K1;PPAP2A;PIP5K1C;PDGFD;AGTR1A
EndocytosisVPS35;CXCR1;DNM3;CDC42;HSP70L;SMURF2;TGFBR2;MET;ZFYVE27
Vascular smooth muscle contractionNPR2;PLCB3;PLA2G1B;RHOAD;NPR1;RHOAA;PLA2G4D;ADCY1B;PLA2G2F
Wnt signaling pathwayVANGL2;NLK1;PRICKLE1A;WNT3;CSNK1A1L;PORCN;PRKACG;PRKACBA;SKP1
TGF-beta signaling pathwayTGIF1;BAMBIA;TGFBR1A;LTBP1;MAPK3;TFDP1A;SMAD1;ACVR1BA;TGIF2
Axon guidanceSRGAP2;RAC3;CNTN6;MYL9;PTK2;SCN3A;ITGB3A;FRS2B;SPRED2
Focal adhesionRHOB;TNXB;PPP1CAB;ITGB6;LAMA3;VAV2;ARHGAP35;RAP1A;PDGFAA
Adherens junctionTGFBR1A;CSNK2A2;PVRL1B;TGFBR1B;INSR;VCL;RAC2;INSRB;VCLA
Tight junctionCLDN5A;MYH13;PARD6GB;SPTAN1;PPP2R2D;CLDN15LA;CLDNA;ACTN1;TJAP1
Platelet activationCOL27A1;P2RX1;RAP1B;AKT1;PLA2G4F;PRKACB;STIM1;ITPR3;MYLK3
T cell receptor signaling pathwayMAPK12;EVLB;NCK2;PPP3CA;CBLB;PIK3R5;CBL;PAK2;IL4
Leukocyte transendothelial migrationCLDN22;ICAM1;CLDN4;PTPN11;PIK3CD;CLDN18;PIK3R1;PLCG2;RASSF5
Neurotrophin signaling pathwayGAB1;SORT1;CAMK2B;FOXO3;ARHGDIA;TP73;CALM1;MAP2K1;MAPK8
Regulation of actin cytoskeletonWASLA;PFN2;FGFR1A;PIK3CB;PFN3;PIP5K1BA;ARAF;LIMK2;FGF6B
Oxytocin signaling pathwayRAF1;RYR3;PLCB4;PIK3CG;PRKAA2;HRAS;ITPR3;MAPK7;MAP2K1
Pancreatic secretionITPR1;CLCA3;RYR2;LOC780933;PLA2G2E;PLCB1;ITPR3;SLC4A4;ATP2B4
Bacterial invasion of epithelial cellsACTG1;SEPT12;ITGA5;CDC42;CAV1;ARPC3;CBL;CLTC;ILK
Pathogenic Escherichia coli infectionTUBB2A;ABL1;CLDN1;TLR4;WASL;OCLN;TUBB1;TUBB2B;TUBB
PertussisNOS2;GM5077;C4BP;CALML3;IRAK1;SERPING1;MAPK12;CASP7;C2
TuberculosisBCL10;IFNA2;ATP6V0D2;IFNA7;MYD88;ATP6V0A1;CEBPG;ATP6V0C;IL10RA
Pathways in cancerGNG5;RAC3;PIK3R2;FZD1;GNAI1;ROCK1;FZD6;RALB;ARHGEF12
Viral carcinogenesisGTF2H2;C3;MAD1L1;ACTN3;HIST1H4F;CCNE1;PSMC1;STAT5B;ACTN4
Proteoglycans in cancerPDCD4;PTPN11;WNT7A;LUM;FASLG;TRP53;MAP2K1;STAT3;PPP1CB
MicroRNAs in cancerCDC25A;RHOA;BMI1;SPRY2;ZFPM2;ABCB1A;PRKCG;NOTCH2;NRAS
Colorectal cancerPIK3R2;RAF1;MLH1;APC;PIK3R3;PIK3R1;BAX;BRAF;APPL1

RHOA has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOA itself. We selected most functions RHOA had, and list some proteins which have the same functions with RHOA. You can find most of the proteins on our site.

Function Related Protein
GDP bindingRAB7A;RAP2B;PIGC;RAB35;RAB8A;RAB4A;PRPS2;RAP1B;RAB31
GTP bindingGTPBP4;ARL1;RRAGCA;ARL4AA;RAB42B;RABL2A;TUBG1;ARL13A;ARF3A
GTPase activityGNB1;EEF1A1;MXA;RAB37;TUBA1B;GNGT2;GNAT3;ARF3;RAB34A
Rho GDP-dissociation inhibitor bindingRAC1;RHOA
myosin bindingSMYD1B;DMD;MYBPC3;RHOA;ARFGEF2;CALM;USH2A;NPHS1;TRIM32
protein bindingIL12A;INPP5A;NAV2;GPSM2;RUSC2;BCL2L11;OSTF1;CAPG;CDK1
protein domain specific bindingTUBB;CBX3;WHRN;MECP2;TFDP2;ICA1;HOMER3;CASKIN1;RAN

RHOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOA here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOA.

RTKN; ARHGDIA; DAAM1; ARHGEF11

Research Area

Related articles

Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
Fichter, CD; Gudernatsch, V; et al. ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. JOURNAL OF MOLECULAR MEDICINE-JMM 92:1209-1223(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is RHOA protein involved in the regulation of blood pressure? 10/26/2021

Yes, RHOA is involved in the regulation of vascular smooth muscle contraction and blood pressure.

What are the potential applications of RHOA inhibitors in cancer therapy? 10/03/2018

RHOA inhibitors may be used to target the metastatic potential of cancer cells and inhibit their ability to spread to other tissues.

Can RHOA inhibitors be used as potential treatments for cardiovascular diseases? 08/02/2018

Yes, RHOA inhibitors may have the potential to be used in the treatment of cardiovascular diseases by targeting vascular smooth muscle contraction.

How is RHOA involved in neurological disorders? 06/24/2017

RHOA has been implicated in the pathogenesis of neurological disorders such as Alzheimer's disease and Parkinson's disease.

Are there any clinical trials investigating the use of RHOA inhibitors in neurological disorders? 01/28/2016

There is emerging research exploring the potential of RHOA inhibitors as a therapeutic approach for neurological disorders.

Customer Reviews (3)

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Reviews
03/04/2021

    Its reliability and versatility make it an essential tool for investigating RHOA protein's expression, function, and structural characteristics.

    01/03/2020

      The use of RHOA protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

      12/21/2018

        RHOA protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.

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