MAPK8
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Official Full Name
mitogen-activated protein kinase 8
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Overview
The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain. -
Synonyms
MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1;
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What is mapk8 protein?
MAPK8 protein, also known as c-Jun N-terminal kinase 1 (JNK1), is a member of the mitogen-activated protein kinase (MAPK) family. It plays a crucial role in various cellular processes, including cell proliferation, differentiation, apoptosis, and immune response.
MAPK8 protein has been implicated in several biological processes and diseases. It has been associated with inflammation, cancer development and progression, neuronal cell survival, and response to stress and environmental stimuli. Dysregulation of MAPK8 signaling has also been linked to neurodegenerative diseases, inflammatory bowel disease, and cardiovascular disorders.
What is the function of mapk8 protein?
In biomedical research, understanding the function and regulation of MAPK8 protein is crucial for developing therapeutic interventions for various diseases. The development of specific inhibitors or activators that target the MAPK8 pathway holds promise for treating conditions such as cancer, inflammation, and neurodegenerative disorders.
Mapk8 related signaling pathway
The MAPK8 protein is involved in a signaling pathway known as the JNK signaling pathway. Upon activation, MAPK8 phosphorylates downstream target proteins, including transcription factors such as c-Jun, ATF2, and Elk-1, leading to gene expression changes and modulation of cellular responses.
Mapk8 Related Diseases
- Cancer: MAPK8 plays a role in tumor development and progression. Abnormal activation of MAPK8 signaling has been found in various cancers, including breast, lung, colon, and pancreatic cancer. Inhibition of MAPK8 signaling is being explored as a potential therapeutic target for cancer treatment.
- Neurodegenerative diseases: Activation of MAPK8 has been observed in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The dysregulation of MAPK8 signaling contributes to neuronal cell death and neuroinflammation in these diseases.
- Cancer therapy: MAPK8 plays a role in regulating cell proliferation, survival, and apoptosis, making it a potential target for cancer therapy. Inhibition of MAPK8 activity has been explored as a strategy to suppress tumor growth and induce apoptosis in cancer cells.
Biomedical Application of mapk8 Protein
- Cancer therapy: MAPK8 plays a role in regulating cell proliferation, survival, and apoptosis, making it a potential target for cancer therapy. Inhibition of MAPK8 activity has been explored as a strategy to suppress tumor growth and induce apoptosis in cancer cells.
- Neuroprotection: MAPK8 is involved in neuronal cell survival and death pathways. Activation of MAPK8 has been shown to protect neurons from various insults, such as oxidative stress and excitotoxicity. Therefore, modulation of MAPK8 activity holds therapeutic potential for neurodegenerative diseases.
High Purity
Fig1. SDS-PAGE (MAPK8-1729H)
(Sorabh Kapoor, 2014)
Fig2. Changes in hepatic cell signaling 5 days after IP. A: Western blots from freshly isolated hepatocytes from three normal donor rats and from three donors at 5 days after IP. β-Tubulin was used as the loading control.
(Hsin-Han Hou, 2014)
Fig3. PGF-activated MAPK8 and MAPK14 signaling pathways are involved in PGF-induced autophagy. (A and B) BEAS-2B cells were pretreated with 100 ng/ml recombinant human PGF for 0 to 24 h. PGF-induced phosphorylation of MAPK8 and MAPK14 was assessed by western blot analysis for p-MAPK8 and p-MAPK14 (A) and the quantitative results are shown in (B).
MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAP3K4;MAPK14A;KRAS;PRKCBA;CACNA1BA;MAP2K4B;PDGFB;FGF5;TGFBR1 |
| ErbB signaling pathway | CBLC;ELK1;PIK3R3;PAK6B;MAP2K2B;ABL2;MAP2K2A;CAMK2D1;MAP2K2 |
| Ras signaling pathway | NGF;RAC3;PRKACB;PLA2G6;CALML3;PRKCG;FOXO4;PIK3R2;SHC4 |
| cAMP signaling pathway | HTR6;PIK3R1;MAPK1;ATP2B4;ROCK1;ATP1B4;GRIN2B;HTR1A;CALM2 |
| FoxO signaling pathway | GADD45BB;TGFBR1A;USP7;RBL2;TGFB2;KRAS;RAG1;IL7R;TGFB3 |
| Sphingolipid signaling pathway | SGPP2;MAP3K5;PPP2CA;NFKB1;PTEN;BID;PIK3R1;PIK3CA;RAC2 |
| Protein processing in endoplasmic reticulum | RRBP1B;P4HB;UBE2D2;MAPK10;UBXN6;SYVN1;SEC13;MAN1A1;CAPN2B |
| Wnt signaling pathway | CCND3;PRKCA;ROCK2A;SFRP4;MMP7;WNT10B;WNT2BB;WNT8B;WNT4A |
| Osteoclast differentiation | IL1R1;MAP2K7;NFKB2;PPP3CB;NCF2;FOSB;FCGR4;GRB2;NOX3 |
| Focal adhesion | PAK3;ITGB1A;CAPN2A;PAK2;TNW;MYLK3;LAMB1A;COL5A1;SRC |
| Toll-like receptor signaling pathway | STAT1;STAT1B;MAP2K4B;MAPK12A;IKBKG;NFKBIA;IL12B;MAPK14A;MAP2K4 |
| NOD-like receptor signaling pathway | TNF;MAPK1;HSP90AA1.1;CXCL8B.3;HSP90AA1;MAPK9;NFKBIA;IL18;NLRP3 |
| RIG-I-like receptor signaling pathway | CASP10;MAPK9;ISG15;AZI2;IFNW1;TBK1;IFNA3;Ifna15;IFNPHI1 |
| Fc epsilon RI signaling pathway | BTK;HRAS;PIK3CD;GAB2;GM-CSF;PRKCA;RAF1;RAC2;AKT1 |
| TNF signaling pathway | FADD;MMP14;PIK3CG;TAB2;MLKL;CREB5;BIRC3;IL18R1;MAP2K7 |
| Neurotrophin signaling pathway | KIDINS220;MAPK7;MAPK12;MAPK13;PRDM4;CAMK2D;MAP2K7;NTF4;GSK3B |
| Retrograde endocannabinoid signaling | NAPEPLD;GABRB2;GABRE;MAPK9;GRIA4;GABRG3;GABRA6;SLC17A7;GRM1 |
| Dopaminergic synapse | GRIA2;CALM4;AKT1;CREB3L3;CALML5;CALML3;PLCB1;PPP2R5E;MAPK9 |
| Inflammatory mediator regulation of TRP channels | TRPV3;PLA2G4D;PRKCG;PPP1CB;CYP2J2;PTGER2;CALM1;CYP4A14;PPP1CA |
| Insulin signaling pathway | PIK3R5;HRASA;SOCS3;SHC4;PRKAR2AB;GYS1;SOCS1;G6PC2;PRKAR2A |
| GnRH signaling pathway | PLD1;CALM;CACNA1C;PLCB2;CDC42L2;ATF4B1;RAF1;PLD2;PLA2G4C |
| Progesterone-mediated oocyte maturation | CCNB2;MAPK12B;HSP90AA1.1;BRAF;PPP1R2P9;MAPK8;FZR1A;PIK3R5;ANAPC1 |
| Prolactin signaling pathway | PIK3R3;STAT3;GSK3B;PPIB;INS;ESR1;MAPK8;SHC4;PRLR |
| Adipocytokine signaling pathway | SLC2A1A;ADIPOR2;PPARA;SOCS3;ADIPOR1B;PPARAB;ACSL1A;PRKAG1;CPT1C |
| Type II diabetes mellitus | INS;IRS1;PIK3CA;PDX1;PIK3CB;MAPK9;HK1;CACNA1G;MAPK8 |
| Insulin resistance | SLC27A3;PPP1CAB;RPS6KA3B;PTPN11A;PTPN1;IRS1;RPS6KB1;PRKCD;PRKAG3 |
| Non-alcoholic fatty liver disease (NAFLD) | PRKAB1;NDUFA3;NDUFB7;NDUFS8;NDUFA8;ADIPOQ;NDUFA4L2;PPARA;INS1 |
| Epithelial cell signaling in Helicobacter pylori infection | ADAM17;ATP6V1C1;GIT1;MAPK8;TJP1;PLCG2;ATP6V1D;PAK1;SRC |
| Shigellosis | U2AF1L4;ABL1;ELMO2;WAS;ELMO1;HCLS1;U2AF1;MAPK10;MAPK3 |
| Salmonella infection | MAPK13;IFNG1-2;ARPC5LB;MAPK1;CXCL1;WASL;RAB7A;CCL3;KLC4 |
| Pertussis | C4BP;GNAI2;MAPK1;MAPK10;Il23a; Il12b;C1RA;IL12B;MAPK13;IL12A |
| Chagas disease (American trypanosomiasis) | SMAD3;IFNB1;IFNG;GNAL;TGFB1;CCL3;GNAI2;CD3E; CD3D;MAPK13 |
| Toxoplasmosis | GNAI1;AKT2;GNAO1;STAT1;IRAK1;PIK3CA;LDLR;IKBKG;LAMA3 |
| Tuberculosis | PPP3R1;Ifna11;CORO1A;PLK3;FCER1G;Il23a;CD209A;TGFB3;IFNGR2 |
| Hepatitis C | IFNA6;MAPK13;PPP2R1A;BRAF;PIK3R5;AKT2;CLDN10;MAPK9;MAPK10 |
| Hepatitis B | NFATC4;PIK3R3;YWHAB;CXCL8;HSPG2;IFNA17;IRF7;CASP10;TLR3 |
| Influenza A | EIF2AK4;AKT2;HSPA2;MAPK8;RNASEL;ACTB;IFNAR2;IFNA1;Ifna15 |
| HTLV-I infection | WNT2;HLA-B;WNT16;TNF;Il2;CCND2;ITGB2L;ATM;GM-CSF |
| Herpes simplex infection | C5;HLA-DMB;USP7;OAS1B;BMA2;NXF1;TLR3;BLB2;NFKB1 |
| Epstein-Barr virus infection | PSMD1;HLA-B;IRF3;MAP3K7;MAPK10;POLR2E;PSMD7;MAP2K7;HLA-DRB3 |
| Pathways in cancer | PRKACA;FGF14;TRAF4;SLC2A1;STAT3;PIK3CB;GNG8;MAPK1;GNG4 |
| Colorectal cancer | AXIN1;MAPK3;PIK3R5;MAPK9;AKT2;RALGDS;LEF1;DCC;TGFB1 |
| Pancreatic cancer | RAC3;SMAD2;RALBP1;RELA;IKBKG;PIK3R2;PIK3R1;ARHGEF6;CDC42 |
| Choline metabolism in cancer | PPAP2A;LYPLA1;HRAS;TSC1;PDGFA;MAPK8;SP1;EGF;KRAS |
MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GM4922;PDPK1;ATAD5;ALPK2;PL10;ATP2B3B;RNASEL;ROCK2A;NME7 |
| JUN kinase activity | ALPK2;MAPK10;MAPK8;MAPK9 |
| enzyme binding | AKT1;MAT2B;Txn1;ECM1;TRP53;IL6R;LDB2;TSPAN15;HNRNPUL1 |
| histone deacetylase binding | CEBPA;HDAC4;XBP1;TRAF6;KAT2B;HOXA10;HES1;HDAC6;HIST1H1B |
| histone deacetylase regulator activity | TP53;NCOR1;TRP53;MAPK8 |
| protein binding | LASP1;KCNG4;TSPAN12;TAF1A;WBP11;UTP14A;VPS8;MAGEC2;MINK1 |
| protein serine/threonine kinase activity | NEK5;RPS6KB2;BCKDK;PKZ;STK32B;MAP4K6;STK4;NIM1;GM4922 |
MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.
JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7
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Q&As (5)
Ask a questionYes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.
MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.
MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.
MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.
Customer Reviews (3)
Write a reviewI am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.
By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.
the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.
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