NOG
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Official Full Name
noggin
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Overview
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. -
Synonyms
NOG; noggin; SYM1; SYNS1;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Dog
- Human
- Mouse
- Mouse/Rat
- Pig
- Rat
- Rhesus Macaque
- CHO
- CHO-K1
- E. coli
- E.coli
- HEK293
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Nicotiana Benthamiana
- NS0
- Wheat Germ
- C
- Fc
- hFc
- His
- GST
- His (Fc)
- Avi
- His|GST
- His|MBP
- Myc
- human|IgG1|Fc
- N/A
- N
- MBP
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- NOG Related Articles
- NOG Related Research Area
NOG involved in several pathways and played different roles in them. We selected most pathways NOG participated on our site, such as BMP receptor signaling, BMP signalling and regulation, Cardiac Progenitor Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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BMP receptor signaling | AHSG;NOG;GREM1;RGMA;SKI;CHRDL1;CTDSP2;SOSTDC1;CTDSP1 |
BMP signalling and regulation | TOB1;NOG |
Cardiac Progenitor Differentiation | NKX2;IRX4;ZFP42;BMP1;TBX5;SIRPA;SOX1;NOG;LIN28A |
Signal Transduction | NPFF;RGS17;PYGO1;CHN2;RCA2.1;CDH5;TAS2R13;ARHGAP11A;LPAR2B |
Signaling by BMP | FSTL1B;SKIB;SKIA;FSTL1A;FSTL1;CHRDL1;CALML4;NOG1;GREM2 |
TGF Beta Signaling Pathway | ENG;NOG;TGFBR3;ZFP423;FOXH1;RUNX3;LEFTY1;FST;ZNF423 |
TGF-beta signaling pathway | BMP7A;BMPR1BB;GDF6A;TGFB2;RHOAD;NOG3;CHRD;SMURF1;ACVR1 |
NOG has several biochemical functions, for example, cytokine binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOG itself. We selected most functions NOG had, and list some proteins which have the same functions with NOG. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
cytokine binding | KITA;CD74;CSF1RA;NRP1;CRLF1;KIT;CHRD;GBP1;IL17F |
protein binding | DTNB;PPP1CB;CLK1;ZCCHC13;COL8A1;HSPA1B;SPG7;INO80E;AKT1S1 |
protein complex binding | HNF1B;CRIPT;RIPK3;TWF1;FADD;UQCRC2;WASF2;PPP1R9B;CPD |
protein homodimerization activity | CCL5;VPS25;STK10;HOMER2;KCNK9;TERF1;TBX15;NTRK1;CAV2 |
NOG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOG here. Most of them are supplied by our site. Hope this information will be useful for your research of NOG.
BMP2; BMP7; GDF5
- Q&As
- Reviews
Q&As (7)
Ask a questionNOG inhibits BMP signaling, critical for tissue development and repair processes.
NOG modulates embryonic patterning and organogenesis, guiding proper organ development.
Changes in NOG expression or function can lead to congenital anomalies due to disrupted developmental processes.
NOG regulates stem cell differentiation, influencing their development into various tissue types.
NOG plays a key role in skeletal development by regulating bone growth and differentiation.
NOG influences neural development, impacting the formation and specialization of neural cells.
NOG is important for joint and cartilage health, potentially impacting arthritis progression.
Customer Reviews (3)
Write a reviewEfficient peptide synthesis, accelerates our peptide research projects.
Fast and reliable protein expression, aids our experiments significantly.
Dependable antibody validation, crucial for our immunoprecipitation studies.
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