Active Recombinant Human IL15
Cat.No. : | IL15-25H |
Product Overview : | Recombinant Human Interleukin-15/IL-15 produced in E. coli is a single non-glycosylated polypeptide chain containing 114 amino acids with a molecular mass of 12.5 kD. |
- Specification
- Gene Information
- Related Products
Description : | Human Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other"s activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature Human IL-15 shares 70% amino acid sequence identity with Mouse and Rat IL-15. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.0. |
Bio-activity : | ED50 is less than 0.5 ng/ml as determined by the dose dependent stimulation of mouse CTLL-2 cell proliferation. Specific Activity of 2.0 x 10^6 IU/mg. |
Endotoxin : | Less than 0.1 EU/μg. |
Purity : | Greater than 95% as determined by RP-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at< -20°c, though stable at room temperature for 3>Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at< -20°c for 3> |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | IL15 interleukin 15 [ Homo sapiens ] |
Official Symbol : | IL15 |
Synonyms : | IL15; interleukin 15; interleukin-15; IL 15; MGC9721; IL-15; |
Gene ID : | 3600 |
mRNA Refseq : | NM_000585 |
Protein Refseq : | NP_000576 |
MIM : | 600554 |
UniProt ID : | P40933 |
Chromosome Location : | 4q31 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; |
Function : | cytokine activity; cytokine receptor binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
Il15-7234M | Active Recombinant Mouse Il15 Protein, His-tagged | +Inquiry |
IL15-01R | Recombinant Rhesus Monkey IL15 Protein, His-tagged | +Inquiry |
IL15-145H | Recombinant Active Human IL15 Protein, His-tagged(N-ter) | +Inquiry |
Il15-091M | Active Recombinant Mouse Il15 Protein | +Inquiry |
IL15-370I | Active Recombinant Human IL15 Protein (121 aa), His-tagged | +Inquiry |
◆ Lysates | ||
IL15-5248HCL | Recombinant Human IL15 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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