Active Recombinant Human SLAMF8, Fc-tagged, Biotinylated

• Cat.No.: SLAMF8-689H
• Product Overview: The recombinant human SLAMF8-Fc fusion protein is expressed as a 440-amino acid protein consisting of Ala23 - Val234 region of SLAMF8 (UniProt accession #Q9P0V8) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Source: Human cells
• Species: Human
• Tag: Fc
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
• Bio-activity: Immobilized SLAMF8 interacts homophilically with SLAMF8 in a functional ELISA
• Molecular Mass: Calculated molecular mass (kDa): 49.1; Estimated by SDS-PAGE under reducing condition (kDa): 65-75
• AA Sequence: AQVLSKVGGSVLLVAARPPGFQVRE AIWRSLWPSEELLATFFRGSLETLY HSRFLGRAQLHSNLSLELGPLESG DSGNFSVLMVDTRGQPWTQTLQLKV YDAVPRPVVQVFIAVERDAQPSKTC QVFLSCWAPNISEITYSWRRETTM DFGMEPHSLFTDGQVLSISLGPGDR DVAYSCIVSNPVSWDLATVTPWDSC HHEAAPGKASYKDVSTGTHTCPPC PAPELLGGPSVFLFPPKPKDTLMIS RTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVV SVLTVLHQDWLNGKEYKCKVSNKAL PAPIEKTISKAKGQPREPQVYTLPP SREEMTKNQVSLTCLVKGFYPSDI AVEWESNGQPENNYKTTPPVLDSDG SFFLYSKLTVDKSRWQQGNVFSCSV MHEALHNHYTQKSLSLSPGK
• Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: SLAMF8 SLAM family member 8 [ Homo sapiens ]
• Official Symbol: SLAMF8
• Synonyms: SLAMF8; SLAM family member 8; BLAME; CD353; SBBI42; BCM-like membrane protein; B lymphocyte activator macrophage expressed; B-lymphocyte activator macrophage expressed; FLJ20442; MGC129578
• Gene ID: 56833
• mRNA Refseq: NM_020125
• Protein Refseq: NP_064510
• MIM: 606620
• UniProt ID: Q9P0V8
• Chromosome Location: 1q23.1
• Function: receptor activity

Reviews

10/19/2021

Perfect for biological assays.

03/03/2021

Product works as expected.

06/20/2020

Very reliable, worth the price.

Q&As

How is SLAMF8 implicated in inflammatory and autoimmune conditions?

Dysregulation of SLAMF8 can contribute to inflammatory and autoimmune diseases.

Are there potential therapeutic interventions targeting SLAMF8?

Therapeutic interventions could potentially target SLAMF8 to modulate immune responses in various diseases.

What role does SLAMF8 play in the regulation of immune responses?

It acts as an inhibitory receptor, modulating immune cell activation and cytokine production.

What are the molecular mechanisms governing SLAMF8 activity?

SLAMF8 activity is governed by interactions with other cell surface receptors and intracellular signaling pathways.

In which immune cells is SLAMF8 predominantly expressed?

SLAMF8 is predominantly found in myeloid cells, like macrophages and dendritic cells.

What is the primary function of SLAMF8 in the immune system?

SLAMF8 regulates immune responses, particularly in myeloid cells.

How does SLAMF8 contribute to immune cell signaling?

It participates in cell-cell signaling, influencing immune cell activation and function.