Active Recombinant Human Colony Stimulating Factor 2 (granulocyte-macrophage)
Cat.No. : | CSF2-470H |
Product Overview : | Recombinant human CSF2 was expressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. MW: 14.6 kDa. |
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Description : | Human CSF2 is a 14.6 kDa globular protein consisting of 128 amino acid containing two dislufied bonds. CSF2 is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. |
Source : | E. coli |
Species : | Human |
Tag : | N/A |
Form : | Liquid in phosphate-buffered saline (pH 7.4). |
Bio-activity : | The ED50 for this effect is< 0.18 ng/ml. measured in a cell proliferation assay using tf1 human erythroleukemic> |
Molecular Mass : | 14.6 kDa (128 aa), confirmed by MALDI-TOF. |
AA Sequence : | MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE |
Endotoxin : | < 1.0 eu per 1 ug of protein (determined by lal |
Purity : | >95% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens ] |
Official Symbol : | CSF2 |
Synonyms : | CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; |
Gene ID : | 1437 |
mRNA Refseq : | NM_000758 |
Protein Refseq : | NP_000749 |
MIM : | 138960 |
UniProt ID : | P04141 |
Chromosome Location : | 5q23-q31 |
Pathway : | Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cytokine activity; granulocyte macrophage colony-stimulating factor receptor binding; growth factor activity; protein binding; |
Products Types
◆ Lysates | ||
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CSF2-740RCL | Recombinant Rat CSF2 cell lysate | +Inquiry |
CSF2-1008MCL | Recombinant Mouse CSF2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionThe sequence of CSF2 is moderately conserved across different species.
The length of CSF2 protein varies but is typically around 144 amino acids.
The primary function of CSF2 is to regulate the production and differentiation of white blood cells.
CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.
CSF2 stands for Colony Stimulating Factor 2.
CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.
CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.
Customer Reviews (3)
Write a reviewThe product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.
The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.
Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.
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