Active Recombinant Human IDO1, His-tagged
Cat.No. : | IDO1-294H |
Product Overview : | Human IDO (aa 1-403) is fused at the C-terminus to a His-tag. |
- Specification
- Gene Information
- Related Products
Description : | IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-γ induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. 0.2μm-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA. |
Bio-activity : | Specific Activity: >100’000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour. |
Molecular Mass : | ~40kDa (SDS-PAGE) |
Purity : | ≥90% (SDS-PAGE) |
Stability : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Concentration : | 1mg/ml |
Gene Name : | IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens ] |
Official Symbol : | IDO1 |
Synonyms : | IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO; IDO-1; |
Gene ID : | 3620 |
mRNA Refseq : | NM_002164 |
Protein Refseq : | NP_002155 |
MIM : | 147435 |
UniProt ID : | P14902 |
Chromosome Location : | 8p12-p11 |
Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Tryptophan catabolism, organism-specific biosystem; Tryptophan metabolism, organism-specific biosystem; |
Function : | electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; tryptophan 2,3-dioxygenase activity; |
Products Types
◆ Recombinant Protein | ||
IDO1-3829H | Recombinant Human IDO1 protein, GST-tagged | +Inquiry |
IDO1-2077M | Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged | +Inquiry |
IDO1-1138H | Recombinant Human IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ido1-1213M | Recombinant Mouse Ido1 Protein, MYC/DDK-tagged | +Inquiry |
IDO1-1419H | Recombinant Human IDO1 Protein (1-403 aa), His-tagged | +Inquiry |
◆ Lysates | ||
IDO1-5300HCL | Recombinant Human IDO1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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