Active Recombinant Human interleukin 17B, HIgG1 Fc-tagged
Cat.No. : | IL17B-317H |
Product Overview : | The extracellular domain of human IL-17B(AAI13926.1)(Gln21-Phe180) is fused to the N-terminus of the Fc region of a human IgG1 was expressed in CHO cell. |
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Description : | The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to induce IL-8 secretion. |
Molecular Mass : | 44KDa (monomer) |
AA Sequence : | Gln21-Phe180 |
Endotoxin : | <0.06 eu/μg as determined by lal>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | IL17B interleukin 17B [ Homo sapiens ] |
Official Symbol : | IL17B |
Synonyms : | IL17B; interleukin 17B; interleukin-17B; IL 17B; IL 20; MGC138900; MGC138901; neuronal interleukin 17 related factor; NIRF; ZCYTO7; interleukin 20; interleukin-20; cytokine Zcyto7; interleukin-17 beta; cytokine-like protein ZCYTO7; neuronal interleukin-17 related factor; neuronal interleukin-17-related factor; IL-20; IL-17B; |
Gene ID : | 27190 |
mRNA Refseq : | NM_014443 |
Protein Refseq : | NP_055258 |
MIM : | 604627 |
UniProt ID : | Q9UHF5 |
Chromosome Location : | 5q33.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cytokine activity; |
Products Types
◆ Lysates | ||
IL17B-5244HCL | Recombinant Human IL17B 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionCo-culture experiments and signaling pathway analysis reveal IL17B's interaction with other cytokines.
Techniques like surface plasmon resonance elucidate IL17B's binding to its receptor.
In vivo models combine IL17B overexpression or neutralization with tumor models to study its role.
Human tissue samples are analyzed using immunohistochemistry and cytokine profiling to understand IL17B's effects.
Flow cytometry and functional assays explore how IL17B affects immune cell activation and cytokine production.
Research uses animal models and biomarker analysis to study IL17B in neuroinflammatory diseases.
Genetic techniques like CRISPR/Cas9 knockout or siRNA knockdown validate IL17B's functional impact.
Transwell assays and impedance-based methods evaluate IL17B's impact on endothelial barrier integrity.
Western blotting and phosphorylation assays uncover IL17B's downstream signaling pathways.
Gene expression analysis involves qPCR or RNA sequencing to distinguish IL17B expression patterns.
Customer Reviews (3)
Write a reviewSuitable for signaling studies.
High solubility
Potent in B-cell assays.
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