Active Recombinant Mouse Mstn

• Cat.No.: Mstn-912M
• Product Overview: Recombinant Mouse Mstn (Accession # O08689) Asp268-Ser376, fused with , was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Mouse
• Predicted N Terminal: Asp268
• Form: Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
• Bio-activity: Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340.The ED50 for this effect is typically 2-10 ng/mL.
• Molecular Mass: Recombinant Mouse Mstn has a calculated MW of 12.4 kDa. In SDS-PAGE migrates as 12 kDa, reducing conditions24 kDa, non-reducing conditions.
• Protein length: Asp268-Ser376
• Purity: >90%, by SDS-PAGE with silver staining.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: Mstn myostatin [ Mus musculus ]
• Official Symbol: Mstn
• Synonyms: MSTN; myostatin; growth/differentiation factor 8; GDF-8; compact; growth differentiation factor 8; Cmpt; Gdf8; MGC124261; MGC124262; MGC124263
• Gene ID: 17700
• mRNA Refseq: NM_010834
• Protein Refseq: NP_034964

Reviews

04/04/2021

The MSTN protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

11/15/2020

the manufacturer of MSTN provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

02/01/2020

The outstanding level of customer service adds extra reassurance and confidence in using the MSTN protein for my scientific investigations.

Q&As

How do MSTN inhibitors work in the context of muscle-related disorders?

MSTN inhibitors work by blocking the activity of the MSTN protein, thus promoting muscle growth and potentially reversing muscle loss.

Are there any known side effects of using MSTN inhibitors in clinical trials?

Some potential side effects include joint stiffness, increased risk of fractures, and insulin resistance, which require close monitoring during trials.

How does the overexpression of MSTN affect muscle development?

Overexpression of MSTN can lead to muscle atrophy and decreased muscle mass.

How do researchers regulate the dosage of MSTN protein therapy to ensure safety and efficacy?

Researchers carefully monitor the dosage and administration of MSTN protein therapy through preclinical and clinical studies to establish the optimal therapeutic dose.

What are the potential risks associated with MSTN protein therapy?

Possible risks include unintended effects on other organ systems and potential complications related to excessive muscle growth.