Recombinant Human Fms-related Tyrosine Kinase 3

• Cat.No.: FLT3-494H

Specification

• Cat. No.: FLT3-494H
• Description: Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems. FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin. FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy.
• Molecular Weight: The predicted molecular weight of Recombinant Human Flt-3 is Mr 85.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 120 kDa.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
• Synonyms: FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FLT3; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III
• Gene ID: 2322
• mRNA Refseq: NM_004119
• Protein Refseq: NP_004110
• MIM: 136351
• UniProt ID: P36888
• Chromosome Location: 13q12
• Pathway: Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
• Function: ATP binding; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity