Recombinant Chicken ANO3
Cat.No. : | ANO3-4324C |
Product Overview : | Recombinant Chicken ANO3 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Chicken |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | ANO3 anoctamin 3 [ Gallus gallus (chicken) ] |
Official Symbol : | ANO3 |
Gene ID : | 422968 |
Protein Refseq : | NP_001186394 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionYes, animal models such as mice and zebrafish have been used to study the role of ANO3 in movement disorders and other physiological processes. These models help researchers understand the impact of ANO3 mutations and provide insights into potential therapeutic interventions.
ANO3 protein is mainly expressed in the brain, particularly in regions such as the neocortex, hippocampus, basal ganglia, and cerebellum. It is also found in the retina and testes, albeit at lower levels.
Yes, ANO3 protein has been implicated in movement disorders. Mutations in the ANO3 gene have been associated with autosomal dominant dystonia, a neurological disorder characterized by involuntary muscle contractions and abnormal movements.
There is currently limited information regarding the role of ANO3 protein in neurotransmitter release. While some studies have detected ANO3 expression in synaptic vesicles, further research is required to fully determine the significance of ANO3 in this process.
Research suggests that ANO3 protein may have additional roles beyond its function as a calcium-activated chloride channel. Some studies have proposed its involvement in pain sensation and regulation of neuronal excitability in the brain.
Future research on ANO3 protein may involve studying its precise role in neuronal excitability, synaptic transmission, and movement disorders. Investigating additional cellular and physiological processes influenced by ANO3 and exploring potential therapeutic interventions are also important areas of future research.
Besides the association with autosomal dominant dystonia, ANO3 mutations have also been linked to essential tremor, a common movement disorder characterized by rhythmic shaking of hands, head, or other body parts. However, the exact mechanisms by which ANO3 dysfunction contributes to these conditions are still being investigated.
As of now, ANO3 protein has not been widely explored as a biomarker for specific diseases. However, ongoing research may reveal its potential as a diagnostic or prognostic indicator for movement disorders or other conditions associated with ANO3 dysfunction.
Yes, ANO3 protein is believed to interact with various proteins to regulate its activity or modulate signaling pathways. For example, ANO3 has been found to interact with proteins involved in calcium signaling and synaptic transmission, including SNAP25 and SHANK proteins.
While there is limited knowledge about specific modulators of ANO3 activity, it is known that phosphorylation can regulate its function. Protein kinase A (PKA) has been shown to phosphorylate ANO3, which may modulate its calcium sensitivity and activity.
Currently, there are no specific small molecules known to modulate ANO3 activity. Discovering compounds that can selectively modulate ANO3 channels may be a focus of future research to explore therapeutic options for ANO3-related disorders.
ANO3 channels are activated by increases in intracellular calcium levels. When calcium ions bind to specific sites on ANO3, it induces conformational changes that open the channel, allowing the flow of chloride ions across the cell membrane.
Currently, there are no specific drugs or therapies targeting ANO3. However, as research on ANO3 continues, it may provide insights into potential therapeutic strategies for movement disorders and other conditions associated with ANO3 dysfunction.
There is evidence suggesting that ANO3 protein plays a role in neuronal development. Studies have shown its expression during embryonic brain development, particularly in regions involved in neurogenesis and neuronal migration. However, further research is needed to understand the specific contributions of ANO3 in neuronal development.
Several mechanisms regulate ANO3 protein activity. Calcium signaling pathways, such as calmodulin binding or activation of protein kinases, can modulate ANO3 function. Post-translational modifications like phosphorylation and palmitoylation have also been suggested to impact ANO3 protein regulation.
Customer Reviews (3)
Write a reviewIts reliability and versatility make it an essential tool for investigating ANO3 protein's expression, function, and structural characteristics.
By visualizing the structural features, interactions, and conformational changes of ANO3, researchers gain valuable insights into its function and potential for therapeutic interventions.
ANO3 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.
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