Recombinant Full Length Human ASB4 Protein, GST-tagged

• Cat.No.: ASB4-1296HF
• Product Overview: Human ASB4 full-length ORF (AAH25024.1, 1 a.a. - 319 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 61.49 kDa
• Protein Length: 319 amino acids
• AA Sequence: MKLKAILIQR QIDVDTVFEV EDENMVLASY KQGYWLPSYK LKSSWATGLH LSVLFGHVEC LLVLLDHNAT INCRPNGKTP LHVACEMANV DCVKILCDRG AKLNCYSLSG HTALHFCTTP SSILCAKQLV WRGANVNMKT NNQDEETPLH TAAHFGLSEL VAFYVEHGAI VDSVNAHMET PLAIAAYWAL RFKEQEYSTE HHLVCRMLLD YKAEVNARDD DFKSPLHKAA WNCDHVLMHM MLEAGAEANL MDINGCAAIQ YVLKVTSVRP AAQPEICYQL LLNHGAARIY PPQFHKVRLC PVVSRLRKIQ MAALSEISK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB4 ankyrin repeat and SOCS box containing 4 [ Homo sapiens ]
• Official Symbol: ASB4
• Synonyms: ASB4; ankyrin repeat and SOCS box containing 4; ankyrin repeat and SOCS box protein 4; ASB 4; ankyrin repeat and SOCS box-containing 4; ASB-4; MGC142039; MGC142041
• Gene ID: 51666
• mRNA Refseq: NM_016116
• Protein Refseq: NP_057200
• MIM: 605761
• UniProt ID: Q9Y574

Reviews

01/30/2023

The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

07/27/2020

the ASB4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

04/03/2016

Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

Q&As

Can ASB4 regulate the degradation of specific target proteins?

Yes, ASB4 interacts with specific target proteins, recognizing them and facilitating their ubiquitination, leading to their subsequent degradation.

Can ASB4 have both cytoplasmic and nuclear functions?

Yes, ASB4 has been observed in both the cytoplasm and the nucleus, suggesting its involvement in diverse cellular compartments and functions.

Is the ASB4 protein conserved across different species?

Yes, ASB4 shows evolutionary conservation, indicating its functional importance across various species.

Does ASB4 have any known substrate specificity?

Yes, ASB4 selectively targets certain proteins for degradation, usually by recognizing specific recognition motifs or interacting with other regulatory factors.

Are there any known interacting proteins that modulate ASB4 activity?

ASB4 can interact with various proteins, including its ubiquitin ligase complex partners or substrate proteins, influencing its activity, localization, or substrate specificity.

Are there any diseases or disorders associated with ASB4 dysfunction?

Currently, there are no known diseases or disorders directly linked to ASB4 dysfunction. However, its dysregulation may potentially contribute to various pathological conditions, requiring further investigation.

What are some of the cellular processes influenced by ASB4-mediated protein degradation?

ASB4-mediated protein degradation can impact cellular processes such as gene expression, signal transduction, cell proliferation, and differentiation.

Can ASB4 play a role in muscle development or function?

Yes, ASB4 has been implicated in skeletal muscle development, differentiation, and regeneration processes based on experimental evidence and studies in animal models.

Are there any drugs or therapeutic interventions targeting ASB4?

Presently, there are no specific drugs targeting ASB4. However, understanding its role and identifying potential modulators may open avenues for therapeutic interventions in the future.

Does ASB4 expression respond to external signals or stimuli?

Yes, ASB4 expression can be regulated by external signals, including hormones, cytokines, growth factors, and cellular stress.