Recombinant Full Length Human ASCC1 Protein, GST-tagged
Cat.No. : | ASCC1-1260HF |
Product Overview : | Human ASCC1 full-length ORF ( NP_057031.2, 1 a.a. - 357 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 67.6 kDa |
Protein Length : | 357 amino acids |
AA Sequence : | MEVLRPQLIR IDGRNYRKNP VQEQTYQHEE DEEDFYQGSM ECADEPCDAY EVEQTPQGFR STLRAPSLLY KHIVGKRGDT RKKIEMETKT SISIPKPGQD GEIVITGQHR NGVISARTRI DVLLDTFRRK QPFTHFLAFF LNEVEVQEGF LRFQEEVLAK CSMDHGVDSS IFQNPKKLHL TIGMLVLLSE EEIQQTCEML QQCKEEFIND ISGGKPLEVE MAGIEYMNDD PGMVDVLYAK VHMKDGSNRL QELVDRVLER FQASGLIVKE WNSVKLHATV MNTLFRKDPN AEGRYNLYTA EGKYIFKERE SFDGRNILKL FENFYFGSLK LNSIHISQRF TVDSFGNYAS CGQIDFS |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens ] |
Official Symbol : | ASCC1 |
Synonyms : | ASCC1; activating signal cointegrator 1 complex subunit 1; ASC1p50; CGI 18; Em:AC022392.3; ASC-1 complex subunit P50; trip4 complex subunit p50; p50; CGI-18 |
Gene ID : | 51008 |
mRNA Refseq : | NM_001198798 |
Protein Refseq : | NP_001185727 |
MIM : | 614215 |
UniProt ID : | Q8N9N2 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionASCC1 is primarily localized in the nucleus of cells, where it functions in gene expression regulation. It is believed to shuttle between the nucleus and cytoplasm upon specific cellular signaling events.
The post-translational modifications of ASCC1 have not been extensively studied. However, it is possible that ASCC1 undergoes modifications such as phosphorylation or acetylation, which can regulate its function.
Yes, ASCC1 is involved in DNA repair processes as part of the ASC-1 complex. It participates in the repair of DNA double-strand breaks, contributing to genome stability.
ASCC1 is expressed in a wide range of tissues and cell types, including but not limited to the brain, liver, heart, and skeletal muscle.
Currently, there are no known human diseases directly associated with ASCC1. However, dysregulation of transcriptional coactivation complexes, in which ASCC1 is involved, can contribute to various diseases.
Given the limited understanding of ASCC1's specific role in diseases, it is currently uncertain if it can be directly targeted for therapeutic interventions or drug discovery.
ASCC1 interacts with various proteins and transcription factors, such as ATF2, TAF12, and TRIM28, to form the ASC-1 complex and regulate gene expression.
Customer Reviews (3)
Write a reviewthe use of ASCC1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
The manufacturer's support and expertise further enhance the utility of ASCC1 in my experimental work, ensuring reliable and high-quality results.
This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.
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