Recombinant Full Length Human ASCC2 Protein, GST-tagged

• Cat.No.: ASCC2-1474HF
• Product Overview: Human ASCC2 full-length ORF ( NP_115580.2, 1 a.a. - 757 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ASCC2 (Activating Signal Cointegrator 1 Complex Subunit 2) is a Protein Coding gene. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 112.8 kDa
• Protein Length: 757 amino acids
• AA Sequence: MPALPLDQLQ ITHKDPKTGK LRTSPALHPE QKADRYFVLY KPPPKDNIPA LVEEYLERAT FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLRYVPR KFDEGVASAP EVVDMQKRLH RSVFLTFLRM STHKESKDHF ISPSAFGEIL YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI GNIFTQQPSY YSDLDETLPT ILQVFSNILQ HCGLQGDGAN TTPQKLEERG RLTPSDMPLL ELKDIVLYLC DTCTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEAAIPEM ESAIKKRRLE DSKLLGDLWQ RLSHSRKKLM EIFHIILNQI CLLPILESSC DNIQGFIEEF LQIFSSLLQE KRFLRDYDAL FPVAEDISLL QQASSVLDET RTAYILQAVE SAWEGVDRRK ATDAKDPSVI EEPNGEPNGV TVTAEAVSQA SSHPENSEEE ECMGAAAAVG PAMCGVELDS LISQVKDLLP DLGEGFILAC LEYYHYDPEQ VINNILEERL APTLSQLDRN LDREMKPDPT PLLTSRHNVF QNDEFDVFSR DSVDLSRVHK GKSTRKEENT RSLLNDKRAV AAQRQRYEQY SVVVEEVPLQ PGESLPYHSV YYEDEYDDTY DGNQVGANDA DSDDELISRR PFTIPQVLRT KVPREGQEED DDDEEDDADE EAPKPDHFVQ DPAVLREKAE ARRMAFLAKK GYRHDSSTAV AGSPRGHGQS RETTQERRKK EANKATRANH NRRTMADRKR SKGMIPS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASCC2 activating signal cointegrator 1 complex subunit 2 [ Homo sapiens ]
• Official Symbol: ASCC2
• Synonyms: ASCC2; activating signal cointegrator 1 complex subunit 2; ASC 1 complex subunit P100; ASC1p100; DKFZp586O0223; FLJ21588; ASC-1 complex subunit P100; trip4 complex subunit p100; p100
• Gene ID: 84164
• mRNA Refseq: NM_001242906
• Protein Refseq: NP_001229835
• MIM: 614216
• UniProt ID: Q9H1I8

Reviews

03/07/2020

Another advantage of using ASCC2 protein in trials is its potential as a therapeutic agent.

05/13/2017

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with ANXA5B.

02/18/2017

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

Q&As

Is there any association between ASCC2 and human diseases?

Currently, there are no known human diseases directly associated with ASCC2. However, dysregulation of transcriptional coactivation complexes, in which ASCC2 is involved, can contribute to various diseases.

Does ASCC2 have any impact on cellular metabolism?

The direct impact of ASCC2 on cellular metabolism is not well-documented. However, given its role in transcriptional regulation, it may indirectly influence metabolic processes by controlling gene expression.

Does ASCC2 undergo any post-translational modifications?

The post-translational modifications of ASCC2 have not been extensively studied. However, it is possible that ASCC2 may undergo modifications such as phosphorylation or acetylation, which can regulate its activity.

How is ASCC2 localized within the cell?

ASCC2 is primarily localized in the nucleus, where it carries out its functions in gene expression regulation.

Is ASCC2 involved in DNA repair processes?

ASCC2 is known to be involved in DNA repair processes as part of the ASC-1 complex. It contributes to the repair of DNA double-strand breaks, promoting genome stability.