Recombinant Full Length Human ATP5C1 Protein, GST-tagged

• Cat.No.: ATP5C1-1388HF
• Product Overview: Human ATP5C1 full-length ORF ( AAH00931, 1 a.a. - 298 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 58.52 kDa
• Protein Length: 298 amino acids
• AA Sequence: MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [ Homo sapiens ]
• Official Symbol: ATP5C1
• Synonyms: ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; ATP5C, ATP5CL1; ATP synthase subunit gamma, mitochondrial; F-ATPase gamma subunit; ATP synthase gamma chain, mitochondrial; mitochondrial ATP synthase, gamma subunit 1; ATP5C; ATP5CL1
• Gene ID: 509
• mRNA Refseq: NM_001001973
• Protein Refseq: NP_001001973
• MIM: 108729
• UniProt ID: P36542

Reviews

04/24/2022

The exceptional stability of this protein makes it an invaluable tool for a wide range of applications.

08/19/2021

Due to the wide application of proteins, researchers can conduct research in more fields and broaden the horizon of scientific research.

05/24/2019

Because the extraordinary activity of proteins makes them valuable tools for a wide range of applications.

Q&As

What are the regulatory mechanisms of ATP5C1?

ATP5C1 expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.

Is ATP5Cexpression associated with the development of specific diseases?

Yes, ATP5C1 expression levels may be associated with the development and progression of certain diseases.

In which tissues or organs is ATP5Chighly expressed?

ATP5C1 is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.

Are ATP5Cgene mutations associated with nervous system diseases?

Yes, ATP5C1 gene mutations are associated with certain neurological diseases such as Parkinson's disease, cerebral ischemia, etc.

Which the role of ATP5Cin tumors?

It may play a role in tumor cell metabolism and energy supply.

What is the role of ATP5Cprotein in metabolic diseases?

ATP5C1 protein may be related to the occurrence and progression of metabolic diseases such as obesity and diabetes.