Recombinant Full Length Human CACUL1 Protein, GST-tagged

• Cat.No.: CACUL1-1686HF
• Product Overview: Human CACUL1 full-length ORF ( AAH38294.1, 1 a.a. - 303 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Enables protein kinase binding activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 60 kDa
• Protein Length: 303 amino acids
• AA Sequence: MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPVSQNF TAV
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CACUL1 CDK2 associated cullin domain 1 [ Homo sapiens (human) ]
• Official Symbol: CACUL1
• Synonyms: C10ORF46; chromosome 10 open reading frame 46; uncharacterized protein C10orf46; FLJ40409; MGC33215; cullin
• Gene ID: 143384
• mRNA Refseq: NM_153810
• Protein Refseq: NP_722517
• MIM: 618764
• UniProt ID: Q86Y37

Reviews

05/12/2022

Product exceeded my expectations!

02/04/2019

Easy to use and effective.

11/28/2018

Great value for the price.

Q&As

How does CACUL1's function relate to its localization within the cell?

CACUL1's subcellular localization varies throughout the cell cycle. It shuttles between the nucleus and cytoplasm, and this dynamic localization is essential for its role in cell cycle regulation and DNA damage response.

How does CACUL1 influence cell cycle progression?

CACUL1 promotes cell cycle progression by forming complexes with CDKs and Cyclins, facilitating their activation. This leads to the phosphorylation of target proteins that drive the cell cycle forward.

What are the key protein-protein interactions involving CACUL1?

CACUL1 interacts with several key cell cycle regulators, including Cyclin-Dependent Kinases (CDKs) and Cyclins. It also interacts with proteins involved in DNA damage repair and checkpoint control.

Can you discuss the role of CACUL1 in epigenetic regulation and chromatin remodeling, and how it impacts gene expression in cancer cells?

Emerging research suggests that CACUL1 is involved in epigenetic regulation by influencing chromatin remodeling processes. It can interact with histone modifiers and transcription factors, leading to changes in gene expression profiles in cancer cells. Understanding these epigenetic mechanisms is vital for targeted cancer therapies.

How is the expression of CACUL1 regulated in normal and cancerous cells?

CACUL1 expression is tightly regulated at the transcriptional level. It is upregulated in many cancer types due to aberrant transcriptional activation, which can be driven by various oncogenic pathways.