Recombinant Full Length Human DCXR Protein, GST-tagged

• Cat.No.: DCXR-2420HF
• Product Overview: Human DCXR full-length ORF ( AAH01470, 1 a.a. - 244 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 52.47 kDa
• Protein Length: 244 amino acids
• AA Sequence: MELFLAGRRVLVTGAGKGIGRGTVQ ALHATGARVVAVSRTQADLDSLVRE CPGIEPVCVDLGDWEATERALGSVG PVDLLVNNAAVALLQPFLEVTKEAF DRSFEVNLRAVIQVSQIVARGLIAR GVPGAIVNVSSQCSQRAVTNHSVYC STKGALDMLTKVMALELGPHKIRVN AVNPTVVMTSMGQATWSDPHKAKTM LNRIPLGKFAEVEHVVNAILFLLSD RSGMTTGSTLPVEGGFWAC
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DCXR dicarbonyl/L-xylulose reductase [ Homo sapiens ]
• Official Symbol: DCXR
• Synonyms: DCXR; dicarbonyl/L-xylulose reductase; L-xylulose reductase; DCR; KIDCR; SDR20C1; short chain dehydrogenase/reductase family 20C; member 1; carbonyl reductase 2; carbonyl reductase II; sperm surface protein P34H; kidney dicarbonyl reductase; short chain dehydrogenase/reductase family 20C, member 1; XR; HCR2; P34H; HCRII
• Gene ID: 51181
• mRNA Refseq: NM_001195218
• Protein Refseq: NP_001182147
• MIM: 608347
• UniProt ID: Q7Z4W1

Reviews

01/25/2022

The staff were enthusiastic and proactive in communicating with me and solving many technical problems in a timely manner.

03/08/2021

The proteins purchased from your company are of very high quality and are suitable for WB experiments.

11/21/2020

DCXR proteins purchased are as advertised and the quality of the product is guaranteed.

Q&As

What are the effects of inhibiting DXCR expression?

Inhibition of DCXR protein expression is associated with male infertility.

Where is the DCXR positioned?

DCXR is a sperm surface protein localized to the sperm acrosome site.

What is the effect of ureaplasma urealyticum infection on DCXR expression?

Ureaplasma urealyticum infection can cause epididymal dysfunction leading to decreased expression of the sperm protein DCXR.

What role does the DXCR play?

DXCR has L-xylulose reductase and bicarbonyl reductase activities that kill bacteria in epididymal fluid.

What is the effect of DCXR expression on sperm viability?

DCXR can remove certain toxic substances and protect spermatozoa to a certain extent and promote sperm maturation and reduce sperm apoptosis.