Recombinant Full Length Human FOXA1 Protein, C-Flag-tagged

• Cat.No.: FOXA1-319HFL
• Product Overview: Recombinant Full Length Human FOXA1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 49 kDa
• AA Sequence: MLGTVKMEGHETSDWNSYYADTQEA YSSVPVSNMNSGLGSMNSMNTYMTM NTMTTSGNMTPASFNMSYAN PGLGAGLSPGAVAGMPGGSAGAMNS MTAAGVTAMGTALSPSGMGAMGAQQ AASMNGLGPYAAAMNPCMSP MAYAPSNLGRSRAGGGGDAKTFKRS YPHAKPPYSYISLITMAIQQAPSKM LTLSEIYQWIMDLFPYYRQN QQRWQNSIRHSLSFNDCFVKVARSP DKPGKGSYWTLHPDSGNMFENGCYL RRQKRFKCEKQPGAGGGGGS GSGGSGAKGGPESRKDPSGASNPSA DSPLHRGVHGKTGQLEGAPAPGPAA SPQTLDHSGATATGGASELK TPASSTAPPISSGPGALASVPASHP AHGLAPHESQLHLKGDPHYSFNHPF SINNLMSSSEQQHKLDFKAY
  EQALQYSPYGSTLPASLPLGSASVT TRSPIEPSALEPAYYQGVYSRPVLN TSTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: ES Cell Differentiation/IPS, Transcription Factors

Gene Information

• Gene Name: FOXA1 forkhead box A1 [ Homo sapiens (human) ]
• Official Symbol: FOXA1
• Synonyms: HNF3A; TCF3A
• Gene ID: 3169
• mRNA Refseq: NM_004496.5
• Protein Refseq: NP_004487.2
• MIM: 602294
• UniProt ID: P55317

Reviews

02/03/2023

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

12/15/2022

Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

06/11/2017

In addition to its scientific merits, the manufacturer of FOXA1 protein stands out for its outstanding technical support.

Q&As

How does FOXA1 protein contribute to the development of liver cancer?

FOXA1 has been implicated in the development and progression of hepatocellular carcinoma, with its expression levels serving as a potential prognostic marker.

Is FOXA1 protein involved in the regulation of estrogen receptor signaling?

Yes, FOXA1 is a key co-regulator of estrogen receptor (ER) signaling, influencing the expression of ER-responsive genes and impacting the response to anti-estrogen therapies.

Can FOXA1 protein expression be used as a predictive biomarker in lung cancer?

FOXA1 expression has been associated with specific subtypes of lung cancer and may hold potential as a predictive biomarker for treatment response.

Are there any clinical trials investigating the role of FOXA1 protein in cancer treatment?

Yes, there are clinical trials focused on understanding the role of FOXA1 in cancer and exploring its potential as a therapeutic target in various cancer types.

How does FOXA1 protein influence the response to anti-androgen therapy in prostate cancer?

High FOXA1 expression has been linked to resistance to anti-androgen therapy in prostate cancer, highlighting its clinical relevance in treatment decision-making.