Recombinant Full Length Human GP1BA Protein, GST-tagged

• Cat.No.: GP1BA-5462HF
• Product Overview: Human GP1BA full-length ORF ( AAH27955.1, 1 a.a. - 626 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 95.4 kDa
• Protein Length: 626 amino acids
• AA Sequence: MPLLLLLLLLPSPLHPHPICEVSKV ASHLEVNCDKRNLTALPPDLPKDTT ILHLSENLLYTFSLATLMPYTRLTQ LNLDRCELTKLQVDGTLPVLGTLDL SHNQLQSLPLLGQTLPALTVLDVSF NRLTSLPLGALRGLGELQELYLKGN ELKTLPPGLLTPTPKLEKLSLANNN LTELPAGLLNGLENLDTLLLQENSL YTIPKGFFGSHLLPFAFLHGNPWLC NCEILYFRRWLQDNAENVYVWKQGV DVKAMTSNVASVQCDNSDKFPVYKY PGKGCPTLGDEGDTDLYDYYPEEDT EGDKVRATRTVVKFPTKAHTTPWGL FYSWSTASLDSQMPSSLHPTQESTK EQTTFPPRWTPNFTLHMESITFSKT PKSTTEPTPSPTTSEPVPEPAPNMT TLEPTPSPTTPEPTSEPAPSPTTPE PTPIPTIATSPTILVSATSLITPKS TFLTTTKPVSLLESTKKTIPELDQP PKLRGVLQGHLESSRNDPFLHPDFC CLLPLGFYVLGLFWLLFASVVLILL LSWVGHVKPQALDSGQGAALTTATQ TTHLELQRGRQVTVPRAWLLFLRGS LPTFRSSLFLWVRPNGRLGPLVAGR RPSALSQGRGQDLLSTVSIRYSGHS L
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GP1BA glycoprotein Ib (platelet), alpha polypeptide [ Homo sapiens ]
• Official Symbol: GP1BA
• Synonyms: GP1BA; glycoprotein Ib (platelet), alpha polypeptide; GP1B; platelet glycoprotein Ib alpha chain; CD42b; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit; BSS; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; MGC34595
• Gene ID: 2811
• mRNA Refseq: NM_000173
• Protein Refseq: NP_000164
• MIM: 606672
• UniProt ID: P07359

Reviews

11/04/2022

Its compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.

04/12/2022

The product's support in the form of educational resources positively impacted the learning curve for our researchers.

06/24/2016

The product's track record of being featured in influential publications positively influenced our decision to use it.

Q&As

What is the primary function of Glycoprotein Ib platelet subunit alpha (GP1BA) in platelet physiology and hemostasis?

Glycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.

What diseases or conditions are associated with dysregulation or abnormal expression of GP1BA?

Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.

How does GP1BA contribute to platelet adhesion and the formation of platelet plugs at sites of vascular injury?

GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.

What are the interactions or binding partners of GP1BA, and how do they influence platelet function?

Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.

How does GP1BA participate in the regulation of blood clotting and coagulation cascades?

GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.

In which cellular compartments is GP1BA predominantly localized, especially within platelets?

GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.

Are there therapeutic implications or potential targets related to GP1BA in diseases involving platelet disorders?

There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.