Recombinant Full Length Human Long-Chain-Fatty-Acid--Coa Ligase 4(Acsl4) Protein, His-Tagged

• Cat.No.: RFL-6383HF
• Product Overview: Recombinant Full Length Human Long-chain-fatty-acid--CoA ligase 4(ACSL4) Protein (O60488) (1-711aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-711)
• AA Sequence: MKLKLNVLTIILLPVHLLITIYSAL IFIPWYFLTNAKKKNAMAKRIKAKP TSDKPGSPYRSVTHFDSLAVIDIPG ADTLDKLFDHAVSKFGKKDSLGTRE ILSEENEMQPNGKVFKKLILGNYKW MNYLEVNRRVNNFGSGLTALGLKPK NTIAIFCETRAEWMIAAQTCFKYNF PLVTLYATLGKEAVVHGLNESEASY LITSVELLESKLKTALLDISCVKHI IYVDNKAINKAEYPEGFEIHSMQSV EELGSNPENLGIPPSRPTPSDMAIV MYTSGSTGRPKGVMMHHSNLIAGMT GQCERIPGLGPKDTYIGYLPLAHVL ELTAEISCFTYGCRIGYSSPLTLSD QSSKIKKGSKGDCTVLKPTLMAAVP EIMDRIYKNVMSKVQEMNYIQKTLF KIGYDYKLEQIKKGYDAPLCNLLLF KKVKALLGGNVRMMLSGGAPLSPQT HRFMNVCFCCPIGQGYGLTESCGAG TVTEVTDYTTGRVGAPLICCEIKLK DWQEGGYTINDKPNPRGEIVIGGQN ISMGYFKNEEKTAEDYSVDENGQRW FCTGDIGEFHPDGCLQIIDRKKDLV KLQAGEYVSLGKVEAALKNCPLIDN ICAFAKSDQSYVISFVVPNQKRLTL LAQQKGVEGTWVDICNNPAMEAEIL KEIREAANAMKLERFEIPIKVRLSP EPWTPETGLVTDAFKLKRKELRNHY LKDIERMYGGK
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: ACSL4
• Synonyms: ACSL4; ACS4; FACL4; LACS4; Long-chain-fatty-acid--CoA ligase 4; Arachidonate--CoA ligase; Long-chain acyl-CoA synthetase 4; LACS 4
• UniProt ID: O60488

Gene Information

• Gene Name: ACSL4
• Synonyms: ACSL4; ACS4; FACL4; LACS4; Long-chain-fatty-acid--CoA ligase 4; Arachidonate--CoA ligase; Long-chain acyl-CoA synthetase 4; LACS 4
• UniProt ID: O60488

Reviews

06/18/2021

High quality product I got from here!

02/23/2020

A+ for this recombinant protein. I don't think I've ever been this excited about a scientific purchase before.

02/01/2020

I'm pretty sure this protein is giving me superpowers. Okay, maybe not, but it's definitely awesome.

11/04/2019

I don't know how you did it, but this protein is like liquid gold. Keep up the good work!

01/18/2019

Can I just say how much I love this company? The protein is great, but the vibes are even better.

Q&As

What is the significance of ACSL4 in the regulation of gene expression?

ACSL4 has been shown to impact gene expression by regulating the availability of long-chain fatty acids for the production of signaling molecules that can impact gene expression.

What is the impact of ACSL4 mutations on human health?

ACSL4 mutations have been linked to a variety of human diseases, including metabolic disorders, neurodegenerative diseases, and cancer.

What is the impact of ACSL4 dysregulation on neurodegenerative diseases?

ACSL4 dysregulation has been linked to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as it can contribute to alterations in lipid metabolism and oxidative stress.

What is the relationship between ACSL4 and oxidative stress?

ACSL4 has been shown to impact oxidative stress, a condition characterized by an imbalance between the production of reactive oxygen species and antioxidant defenses, by regulating the availability of long-chain fatty acids for the production of antioxidant molecules.

What is the role of ACSL4 in mitochondrial function?

ACSL4 has been shown to impact mitochondrial function by regulating the availability of long-chain fatty acids for energy production and cellular signaling pathways.

What is the significance of ACSL4 in the development of cancer?

ACSL4 dysregulation has been implicated in the development of cancer, as it can promote tumor cell survival and growth by altering lipid metabolism and signaling pathways.

What is the relationship between ACSL4 and inflammation?

ACSL4 has been shown to play a role in inflammation by regulating the availability of long-chain fatty acids for the production of inflammatory mediators, such as prostaglandins and leukotrienes.

What is the impact of ACSL4 dysregulation on insulin sensitivity?

ACSL4 dysregulation has been linked to the development of insulin resistance, a condition characterized by impaired glucose uptake and utilization, which can contribute to the development of metabolic disorders, such as obesity and diabetes.

What are the regulatory mechanisms that control ACSL4 expression?

ACSL4 expression is regulated by a variety of mechanisms, including transcriptional regulation, post-transcriptional regulation, and post-translational modifications.

What is the expression pattern of the ACSL4 gene?

The ACSL4 gene is expressed in a variety of tissues, including adipose tissue, liver, muscle, heart, and brain.