| Description : |
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
89.1 kDa |
| Protein Length : |
557 amino acids |
| AA Sequence : |
MRDYDEVTAFLGEWGPFQRLIFFLL SASIIPNGFTGLSSVFLIATPEHRC RVPDAANLSSAWRNHTVPLRLRDGR EVPHSCRRYRLATIANFSALGLEPG RDVDLGQLEQESCPDGWEFSQDVYL STIVTEWNLVCEDDWKAPLTISLFF VGVLLGSFISGQLSDRFGRKNVLFV TMGMQTGFSFLQIFSKNFEMFVVLF VLVGMGQISNYVAAFVLGTEILGKS VRIIFSTLGVCIFYAFGYMVLPLFA YFIRDWRMLLVALTMPGVLCVALWW FIPESPRWLISQGRFEEAEVIIRKA AKANGIVVPSTIFDPSELQDLSSKK QQSHNILDLLRTWNIRMVTIMSIML WMTISVGYFGLSLDTPNLHGDIFVN CFLSAMVEVPAYVLAWLLLQYLPRR YSMATALFLGGSVLLFMQLVPPDLY YLATVLVMVGKFGVTAAFSMVYVYT AELYPTVVRNMGVGVSSTASRLGSI LSPYFVYLGAYDRFLPYILMGSLTI LTAILTLFLPESFGTPLPDTIDQML RVKGMKHRKTPSHTRMLKDGQERPT ILKSTAF |
| Applications : |
Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
| Notes : |
Best use within three months from the date of receipt of this protein |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
