Recombinant Human ABCC4 protein, His & T7-tagged
Cat.No. : | ABCC4-8119H |
Product Overview : | Recombinant Human ABCC4 aa. (Ile1041~Gln1274 (Accession # O15439)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
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Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 30.2kDa. |
Protein length : | Ile1041~Gln1274 (Accession # O15439) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 6.0. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage Buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | ABCC4 ATP binding cassette subfamily C member 4 [ Homo sapiens (human) ] |
Official Symbol : | ABCC4 |
Gene ID : | 10257 |
mRNA Refseq : | NM_001105515.2 |
Protein Refseq : | NP_001098985.1 |
UniProt ID : | O15439 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionABCC4 is required for cell proliferation and tumorigenesis in non-small cell lung cancer. The percentage of cells in G1 phase was increased when ABCC4 expression was suppressed.
Study show that ABCC4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.
Cancer,inflammatory bowel disease,Cardiovascular disease,Neurological disorders and so on.
Specific for different ABCC protein, may reduced growth, migration and invasion.
cAMP/Epac-PKA pathway,MEK/ERK or PI3K/AKT signaling pathway, depends on different functions.
MRP4/ABCC4 is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells.
Some results show that MRP4 (ABCC4) is a potential pharmacologic target for cardiovascular disease.
ABCC4 is capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell, such as cyclic nucleotides, eicosanoids, urate and conjugated steroids.
MK571 or sorafenib, as well as after ABCC4 siRNA
Yes, MRP4 or ABCC4 that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions.
The protein is composed of 1,522 amino acids and has a predicted molecular weight of approximately 171 kDa.But the crystal structure of MRP4 has not yet been determined.
One research show that miR-124a and miR-506 expression was negatively correlated with MRP4 protein expression in 26 human kidney samples.
ABCC4 is primarily expressed on the plasma membrane. The ABCC4 membrane transporter modulates platelet aggregation
Yes, a previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ABCC4 gene in most European populations.
A prolonged inhibition of MRP4 can promote cardiac hypertrophy, and MRP4 inhibition in platelets induces a moderate thrombopathy.
Customer Reviews (3)
Write a reviewIt's good for immune test
Nice Protein
Natural protein concentration is very high
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