Recombinant Zebrafish ABCC4
Cat.No. : | ABCC4-1621Z |
Product Overview : | Recombinant Zebrafish ABCC4 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 [ Danio rerio (zebrafish) ] |
Official Symbol : | ABCC4 |
Gene ID : | 368620 |
mRNA Refseq : | NM_001007038 |
Protein Refseq : | NP_001007039 |
UniProt ID : | Q8QFL6 |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionABCC4 is required for cell proliferation and tumorigenesis in non-small cell lung cancer. The percentage of cells in G1 phase was increased when ABCC4 expression was suppressed.
Study show that ABCC4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.
Cancer,inflammatory bowel disease,Cardiovascular disease,Neurological disorders and so on.
Specific for different ABCC protein, may reduced growth, migration and invasion.
cAMP/Epac-PKA pathway,MEK/ERK or PI3K/AKT signaling pathway, depends on different functions.
MRP4/ABCC4 is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells.
Some results show that MRP4 (ABCC4) is a potential pharmacologic target for cardiovascular disease.
ABCC4 is capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell, such as cyclic nucleotides, eicosanoids, urate and conjugated steroids.
MK571 or sorafenib, as well as after ABCC4 siRNA
Yes, MRP4 or ABCC4 that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions.
The protein is composed of 1,522 amino acids and has a predicted molecular weight of approximately 171 kDa.But the crystal structure of MRP4 has not yet been determined.
One research show that miR-124a and miR-506 expression was negatively correlated with MRP4 protein expression in 26 human kidney samples.
ABCC4 is primarily expressed on the plasma membrane. The ABCC4 membrane transporter modulates platelet aggregation
Yes, a previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ABCC4 gene in most European populations.
A prolonged inhibition of MRP4 can promote cardiac hypertrophy, and MRP4 inhibition in platelets induces a moderate thrombopathy.
Customer Reviews (3)
Write a reviewIt's good for immune test
Nice Protein
Natural protein concentration is very high
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