Recombinant Human ACAP2 Protein, GST-Tagged

• Cat.No.: ACAP2-0003H
• Product Overview: Human CENTB2 full-length ORF (NP_036419.2, 1 a.a. - 778 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2) is a Protein Coding gene. Among its related pathways are Arf6 signaling events and Endocytosis. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is ACAP3.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 114.5 kDa
• AA Sequence: MKMTVDFEECLKDSPRFRAALEEVE GDVAELELKLDKLVKLCIAMIDTGK AFCVANKQFMNGIRDLAQYSSNDAV VETSLTKFSDSLQEMINFHTILFDQ TQRSIKAQLQNFVKEDLRKFKDAKK QFEKVSEEKENALVKNAQVQRNKQH EVEEATNILTATRKCFRHIALDYVL QINVLQSKRRSEILKSMLSFMYAHL AFFHQGYDLFSELGPYMKDLGAQLD RLVVDAAKEKREMEQKHSTIQQKDF SSDDSKLEYNVDAANGIVMEGYLFK RASNAFKTWNRRWFSIQNNQLVYQK KFKDNPTVVVEDLRLCTVKHCEDIE RRFCFEVVSPTKSCMLQADSEKLRQ AWIKAVQTSIATAYREKGDESEKLD KKSSPSTGSLDSGNESKEKLLKGES ALQRVQCIPGNASCCDCGLADPRWA SINLGITLCIECSGIHRSLGVHFSK VRSLTLDTWEPELLKLMCELGNDVI NRVYEANVEKMGIKKPQPGQRQEKE AYIRAKYVERKFVDKYSISLSPPEQ QKKFVSKSSEEKRLSISKFGPGDQV RASAQSSVRSNDSEIQQSSDDGRES LPSTVSANSLYEPEGERQDSSMFLD SKHLNPGLQLYRASYEKNLPKMAEA LAHGADVNWANSEENKATPLIQAVL GGSLVTCEFLLQNGANVNQRDVQGR GPLHHATVLGHTGQVCLFLKRGANQ HATDEEGKDPLSIAVEAANADIVTL LRLARMNEEMRESEGLYGQPGDETY QDIFRDFSQMASNNPEKLNRFQQDS QKF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Homo sapiens ]
• Official Symbol: ACAP2
• Synonyms: ACAP2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; centaurin, beta 2, CENTB2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; CNT B2; KIAA0041; centaurin-beta-2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; CENTB2; CNT-B2
• Gene ID: 23527
• mRNA Refseq: NM_012287
• Protein Refseq: NP_036419
• MIM: 607766
• UniProt ID: Q15057

Reviews

08/10/2021

I am very satisfied with the recombinant human ACAP2 protein. The product was of high quality and helped me achieve excellent results.

10/12/2020

I have had nothing but positive experiences with Creative BioMart. Their recombinant ACAP2 proteins are consistently high-quality and their customer service is excellent.

09/18/2020

Thanks to Creative BioMart's recombinant ACAP2 proteins, my research has progressed much more quickly than I had anticipated.

Q&As

Is there any discount for ACAP2 recombinant protein?

We are offering a 10% discount on all products for a limited time. The clock is ticking down. Be sure to take advantage of our holiday promotions!

What applications can recombinant ACAP2 protein be used for?

Recombinant ACAP2 protein can be used for various applications, such as biochemical assays, protein-protein interaction studies, and drug discovery. It can also be used as an immunogen for antibody production or as a standard in ELISA assays.

Can the recombinant ACAP2 protein be used in in vitro or in vivo assays?

Recombinant ACAP2 protein can be used in both in vitro and in vivo assays, depending on your research needs. In vitro assays can include biochemical assays, protein-protein interaction studies, and enzymatic assays, while in vivo assays can include cell-based assays or animal models.

What is the role of ACAP2 in cytokinesis?

ACAP2 is involved in the regulation of cytokinesis by controlling the activity of RhoA, a small GTPase that plays a critical role in the formation of the contractile ring. ACAP2 interacts with RhoA and regulates its activity, which is necessary for the proper formation and contraction of the contractile ring.

What is the function of ACAP2 in endocytic trafficking?

ACAP2 is involved in the regulation of clathrin-mediated endocytosis (CME) by controlling the formation of clathrin-coated vesicles. It interacts with multiple proteins such as AP2, Eps15, and dynamin, and regulates the activity of Arf6 GTPase, which is essential for the formation of clathrin-coated vesicles.

Can the recombinant human ACAP2 protein be customized or modified to suit specific research needs?

Creative BioMart offers customization or modification services for recombinant ACAP2 protein, such as adding tags or modifying the protein sequence.

What is the price of recombinant human ACAP2 protein?

It depends on the specific product. Generally, the price is based on factors such as purity, quantity, and functional activity. Please submit an inquiry form for specific products, or contact our technical support staff for consultation.

Does the recombinant ACAP2 protein have any post-translational modifications?

The presence or absence of post-translational modifications in recombinant ACAP2 protein can vary depending on the expression system and the purification method used. We support custom production of recombinant proteins, and you can describe your specific research requirements when submitting the online inquiry form.

How does ACAP2 regulate cell migration?

ACAP2 is involved in the regulation of cell migration by controlling the activity of Rac1, a small GTPase that plays a critical role in the formation of lamellipodia and membrane ruffling. ACAP2 interacts with Rac1 and regulates its activity, which is necessary for the formation of these structures during cell migration.

What is the significance of ACAP2 in cancer?

ACAP2 has been shown to play a critical role in the regulation of cell proliferation and survival, and its dysregulation has been linked to the development and progression of various types of cancer. ACAP2 has been shown to be upregulated in several types of cancer, including breast, lung, and liver cancer, and its inhibition has been proposed as a potential therapeutic strategy for cancer treatment.