Recombinant Human ACRBP Protein, GST-Tagged
Cat.No. : | ACRBP-187H |
Product Overview : | Human ACRBP full-length ORF ( NP_115878.2, 1 a.a. - 543 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 87.8 kDa |
AA Sequence : | MRKPAAGFLPSLLKVLLLPLAPAAA QDSTQASTPGSPLSPTEYERFFALL TPTWKAETTCRLRATHGCRNPTLVQ LDQYENHGLVPDGAVCSNLPYASWF ESFCQFTHYRCSNHVYYAKRVLCSQ PVSILSPNTLKEIEASAEVSPTTMT SPISPHFTVTERQTFQPWPERLSNN VEELLQSSLSLGGQEQAPEHKQEQG VEHRQEPTQEHKQEEGQKQEEQEEE QEEEGKQEEGQGTKEGREAVSQLQT DSEPKFHSESLSSNPSSFAPRVREV ESTPMIMENIQELIRSAQEIDEMNE IYDENSYWRNQNPGSLLQLPHTEAL LVLCYSIVENTCIITPTAKAWKYME EEILGFGKSVCDSLGRRHMSTCALC DFCSLKLEQCHSEASLQRQQCDTSH KTPFVSPLLASQSLSIGNQVGSPES GRFYGLDLYGGLHMDFWCARLATKG CEDVRVSGWLQTEFLSFQDGDFPTK ICDTDYIQYPNYCSFKSQQCLMRNR NRKVSRMRCLQNETYSALSPGKSED VVLRWSQEFSTLTLGQFG |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
SDS-PAGE: |
Gene Name : | ACRBP acrosin binding protein [ Homo sapiens ] |
Official Symbol : | ACRBP |
Synonyms : | ACRBP; acrosin binding protein; acrosin-binding protein; cancer/testis antigen 23; CT23; OY TES 1; proacrosin binding protein sp32; SP32; cancer/testis antigen OY-TES-1; OY-TES-1; FLJ51160; |
Gene ID : | 84519 |
mRNA Refseq : | NM_032489 |
Protein Refseq : | NP_115878 |
MIM : | 608352 |
UniProt ID : | Q8NEB7 |
Products Types
◆ Recombinant Protein | ||
ACRBP-267M | Recombinant Mouse ACRBP Protein, His (Fc)-Avi-tagged | +Inquiry |
ACRBP-121R | Recombinant Rat ACRBP Protein, His (Fc)-Avi-tagged | +Inquiry |
ACRBP-1219M | Recombinant Mouse ACRBP Protein | +Inquiry |
ACRBP-155H | Recombinant Human ACRBP Protein, HIS-tagged | +Inquiry |
ACRBP-465R | Recombinant Rat ACRBP Protein | +Inquiry |
◆ Lysates | ||
ACRBP-9080HCL | Recombinant Human ACRBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe ACRBP gene expression is regulated by multiple factors during spermatogenesis, including androgens and retinoic acid.
The Cys-His repeats in the ACRBP protein are thought to be involved in the binding of acrosin, a protease involved in sperm function.
Mutations in the ACRBP gene have been associated with male infertility, and dysregulated expression of the gene has been implicated in several reproductive disorders.
The ACRBP protein contains several domains, including a signal peptide, a N-terminal proline-rich domain, a central domain with multiple repeats of a Cys-His motif, and a C-terminal domain with a conserved CUB (complement C1r/C1s, Uegf, and bone morphogenetic protein-1) domain.
The ACRBP gene product is involved in the regulation of acrosin activity during spermatogenesis.
The ACRBP protein can undergo several post-translational modifications, including phosphorylation, glycosylation, and proteolytic cleavage.
The ACRBP protein is transported and localized within the cell by a signal peptide that targets it to the endoplasmic reticulum and Golgi apparatus.
The tissue distribution of the ACRBP gene in non-human species varies depending on the species, but it is primarily expressed in the male reproductive system.
The CUB domain of the ACRBP protein is thought to be involved in protein-protein interactions with other molecules involved in sperm function.
The ACRBP gene is primarily expressed in the testis, specifically in the seminiferous tubules and epididymis.
Customer Reviews (5)
Write a reviewThe manufacturer's products have good batch control, and the quality of the protein is stable every time.
The samples provided by the manufacturer make it easier for me to choose the most suitable protein.
The manufacturer provides comprehensive after-sales service, and I am very satisfied with this.
The quality of the manufacturer's products is consistent, and I have always been their loyal customer.
The protein price is reasonable, and I feel that it is worth the money.
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