Recombinant Human ACRBP Protein, HIS-tagged

• Cat.No.: ACRBP-155H
• Product Overview: Recombinant Human ACRBP fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon.
• Source: E. coli
• Tag: HIS
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 58.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ACRBP acrosin binding protein [ Homo sapiens ]
• Official Symbol: ACRBP
• Synonyms: ACRBP; acrosin binding protein; acrosin-binding protein; cancer/testis antigen 23; CT23; OY TES 1; proacrosin binding protein sp32; SP32; cancer/testis antigen OY-TES-1; OY-TES-1; FLJ51160
• Gene ID: 84519
• mRNA Refseq: NM_032489
• Protein Refseq: NP_115878
• MIM: 608352
• UniProt ID: Q8NEB7

Reviews

01/18/2020

The manufacturer's products have good batch control, and the quality of the protein is stable every time.

01/12/2020

The samples provided by the manufacturer make it easier for me to choose the most suitable protein.

07/30/2019

The manufacturer provides comprehensive after-sales service, and I am very satisfied with this.

04/22/2019

The quality of the manufacturer's products is consistent, and I have always been their loyal customer.

05/11/2018

The protein price is reasonable, and I feel that it is worth the money.

Q&As

How is the ACRBP gene expression regulated during spermatogenesis?

The ACRBP gene expression is regulated by multiple factors during spermatogenesis, including androgens and retinoic acid.

What is the role of the Cys-His repeats in the ACRBP protein?

The Cys-His repeats in the ACRBP protein are thought to be involved in the binding of acrosin, a protease involved in sperm function.

What is the clinical significance of the ACRBP gene?

Mutations in the ACRBP gene have been associated with male infertility, and dysregulated expression of the gene has been implicated in several reproductive disorders.

What is the protein structure of the ACRBP protein?

The ACRBP protein contains several domains, including a signal peptide, a N-terminal proline-rich domain, a central domain with multiple repeats of a Cys-His motif, and a C-terminal domain with a conserved CUB (complement C1r/C1s, Uegf, and bone morphogenetic protein-1) domain.

What is the function of the ACRBP gene product?

The ACRBP gene product is involved in the regulation of acrosin activity during spermatogenesis.

What post-translational modifications can occur on the ACRBP protein?

The ACRBP protein can undergo several post-translational modifications, including phosphorylation, glycosylation, and proteolytic cleavage.

How is the ACRBP protein transported and localized within the cell?

The ACRBP protein is transported and localized within the cell by a signal peptide that targets it to the endoplasmic reticulum and Golgi apparatus.

What is the tissue distribution of the ACRBP gene in non-human species?

The tissue distribution of the ACRBP gene in non-human species varies depending on the species, but it is primarily expressed in the male reproductive system.

What is the role of the CUB domain in the ACRBP protein?

The CUB domain of the ACRBP protein is thought to be involved in protein-protein interactions with other molecules involved in sperm function.

What is the expression pattern of the ACRBP gene?

The ACRBP gene is primarily expressed in the testis, specifically in the seminiferous tubules and epididymis.