Recombinant Human ACSL4 Protein, GST-tagged
Cat.No. : | ACSL4-198H |
Product Overview : | Human ACSL4 full-length ORF ( NP_004449.1, 1 a.a. - 670 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 100.8 kDa |
AA Sequence : | MAKRIKAKPTSDKPGSPYRSVTHFD SLAVIDIPGADTLDKLFDHAVSKFG KKDSLGTREILSEENEMQPNGKVFK KLILGNYKWMNYLEVNRRVNNFGSG LTALGLKPKNTIAIFCETRAEWMIA AQTCFKYNFPLVTLYATLGKEAVVH GLNESEASYLITSVELLESKLKTAL LDISCVKHIIYVDNKAINKAEYPEG FEIHSMQSVEELGSNPENLGIPPSR PTPSDMAIVMYTSGSTGRPKGVMMH HSNLIAGMTGQCERIPGLGPKDTYI GYLPLAHVLELTAEISCFTYGCRIG YSSPLTLSDQSSKIKKGSKGDCTVL KPTLMAAVPEIMDRIYKNVMSKVQE MNYIQKTLFKIGYDYKLEQIKKGYD APLCNLLLFKKVKALLGGNVRMMLS GGAPLSPQTHRFMNVCFCCPIGQGY GLTESCGAGTVTEVTDYTTGRVGAP LICCEIKLKDWQEGGYTINDKPNPR GEIVIGGQNISMGYFKNEEKTAEDY SVDENGQRWFCTGDIGEFHPDGCLQ IIDRKKDLVKLQAGEYVSLGKVEAA LKNCPLIDNICAFAKSDQSYVISFV VPNQKRLTLLAQQKGVEGTWVDICN NPAMEAEILKEIREAANAMKLERFE IPIKVRLSPEPWTPETGLVTDAFKL KRKELRNHYLKDIERMYGGK |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ACSL4 acyl-CoA synthetase long-chain family member 4 [ Homo sapiens ] |
Official Symbol : | ACSL4 |
Synonyms : | ACSL4; acyl-CoA synthetase long-chain family member 4; FACL4, fatty acid Coenzyme A ligase, long chain 4 , mental retardation, X linked 63 , mental retardation, X linked 68 , MRX63, MRX68; long-chain-fatty-acid--CoA ligase 4; long chain fatty acid Coenzyme A ligase 4; ACS4; LACS4; lignoceroyl CoA synthase; LACS 4; acyl-CoA synthetase 4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; fatty-acid-Coenzyme A ligase, long-chain 4; FACL4; MRX63; MRX68; |
Gene ID : | 2182 |
mRNA Refseq : | NM_004458 |
Protein Refseq : | NP_004449 |
MIM : | 300157 |
UniProt ID : | O60488 |
Products Types
◆ Recombinant Protein | ||
ACSL4-46R | Recombinant Rhesus Macaque ACSL4 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACSL4-127R | Recombinant Rat ACSL4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Acsl4-1507M | Recombinant Mouse Acsl4 Protein, Myc/DDK-tagged | +Inquiry |
Acsl4-56R | Recombinant Rat Acsl4 Protein, His-tagged | +Inquiry |
ACSL4-55H | Recombinant Human ACSL4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ACSL4-9074HCL | Recombinant Human ACSL4 293 Cell Lysate | +Inquiry |
ACSL4-9075HCL | Recombinant Human ACSL4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionACSL4 has been shown to impact gene expression by regulating the availability of long-chain fatty acids for the production of signaling molecules that can impact gene expression.
ACSL4 mutations have been linked to a variety of human diseases, including metabolic disorders, neurodegenerative diseases, and cancer.
ACSL4 dysregulation has been linked to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as it can contribute to alterations in lipid metabolism and oxidative stress.
ACSL4 has been shown to impact oxidative stress, a condition characterized by an imbalance between the production of reactive oxygen species and antioxidant defenses, by regulating the availability of long-chain fatty acids for the production of antioxidant molecules.
ACSL4 has been shown to impact mitochondrial function by regulating the availability of long-chain fatty acids for energy production and cellular signaling pathways.
ACSL4 dysregulation has been implicated in the development of cancer, as it can promote tumor cell survival and growth by altering lipid metabolism and signaling pathways.
ACSL4 has been shown to play a role in inflammation by regulating the availability of long-chain fatty acids for the production of inflammatory mediators, such as prostaglandins and leukotrienes.
ACSL4 dysregulation has been linked to the development of insulin resistance, a condition characterized by impaired glucose uptake and utilization, which can contribute to the development of metabolic disorders, such as obesity and diabetes.
ACSL4 expression is regulated by a variety of mechanisms, including transcriptional regulation, post-transcriptional regulation, and post-translational modifications.
The ACSL4 gene is expressed in a variety of tissues, including adipose tissue, liver, muscle, heart, and brain.
Customer Reviews (5)
Write a reviewHigh quality product I got from here!
A+ for this recombinant protein. I don't think I've ever been this excited about a scientific purchase before.
I'm pretty sure this protein is giving me superpowers. Okay, maybe not, but it's definitely awesome.
I don't know how you did it, but this protein is like liquid gold. Keep up the good work!
Can I just say how much I love this company? The protein is great, but the vibes are even better.
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