Recombinant Human ACSM2A Protein, GST-tagged
Cat.No. : | ACSM2A-205H |
Product Overview : | Human ACSM2A full-length ORF (BAG53201.1, 1 a.a. - 577 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 89.87 kDa |
AA Sequence : | MHWLRKVQGLCTLWGTQMSSRTLYI NSRQLVSLQWGHQEVPAKFNFASDV LDHWADMEKAGKRLPSPALWWVNGK GKELMWNFRELSENSQQAANVLSGA CGLQRGDRVAVVLPRVPEWWLVILG CIRAGLIFMPGTIQMKSTDILYRLQ MSKAKAIVAGDEVIQEVDTVASECP SLRIKLLVSEKSCDGWLNFKKLLNE ASTTHHCVETGSQEASAIYFTSGTS GLPKMAEHSYSSLGLKAKMDAGWTG LQASDIMWTISDTGWILNILCSLME PWALGACTFVHLLPKFDPLVILKTL SSYPIKSMMGAPIVYRMLLQQDLSS YKFPHLQNCVTVGESLLPETLENWR AQTGLDIRESYGQTETGLTCMVSKT MKIKPGYMGTAASCYDVQIIDDKGN VLPPGTEGDIGIRVKPIRPIGIFSG YVDNPDKTAANIRGDFWLLGDRGIK DEDGYFQFMGRADDIINSSGYRIGP SEVENALMEHPAVVETAVISSPDPV RGEVVKAFVVLASQFLSHDPEQLTK ELQQHVKSVTAPYKYPRKIEFVLNL PKTVTGKIQRAKLRDKEWKMSGKAR AQ |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ACSM2A acyl-CoA synthetase medium-chain family member 2A [ Homo sapiens ] |
Official Symbol : | ACSM2A |
Synonyms : | ACSM2; A-923A4.1 |
Gene ID : | 123876 |
mRNA Refseq : | NM_001010845.2 |
Protein Refseq : | NP_001010845.1 |
MIM : | 614358 |
UniProt ID : | Q08AH3 |
Products Types
◆ Recombinant Protein | ||
Acsm2a-3135R | Recombinant Rat Acsm2a, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionRecent studies have suggested that ACSM2A plays a critical role in cancer metabolism by regulating the uptake and utilization of fatty acids by cancer cells.
ACSM2A has been shown to be highly expressed in skeletal muscle and may play a role in regulating muscle function and metabolism. Studies have suggested that ACSM2A may be involved in the regulation of glucose uptake and glycogen synthesis in muscle cells.
ACSM2A is known to interact with several cellular proteins and signaling pathways, including the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors and the AMP-activated protein kinase (AMPK) pathway. Further investigation is needed to fully understand the functional significance of these interactions.
ACSM2A-mediated insulin resistance is thought to be due to the accumulation of lipid intermediates, such as diacylglycerols and ceramides, which interfere with insulin signaling.
ACSM2A expression has been shown to be upregulated in various types of cancer, including breast cancer and pancreatic cancer, and may serve as a potential therapeutic target for cancer treatment.
Recent studies have suggested that ACSM2A expression is regulated by the tumor microenvironment, including hypoxia and inflammatory cytokines, in cancer cells.
Inhibition of ACSM2A activity has been shown to suppress the growth and survival of colorectal cancer cells, suggesting that ACSM2A may serve as a potential therapeutic target for colorectal cancer treatment.
The precise mechanism by which ACSM2A regulates tumor growth and survival in cancer cells is not fully understood. However, recent studies suggest that ACSM2A may modulate fatty acid metabolism and mitochondrial function to support cancer cell growth and survival.
ACSM2A has been implicated in the development of liver steatosis by promoting the uptake and accumulation of fatty acids in hepatocytes.
ACSM2A deficiency has been shown to impair mitochondrial β-oxidation and energy metabolism, leading to metabolic dysfunction.
Customer Reviews (5)
Write a reviewSo grateful for its performance!
It seamlessly integrates into our experimental systems, enabling precise control and manipulation. It has greatly expanded the scope of our investigations.
The functionality of this protein is outstanding.
Affordable pricing without compromising on quality. Highly satisfied with the product.
We are exceedingly satisfied with the quality of this protein.
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