Recombinant Rat Acsm2a, His-tagged

• Cat.No.: Acsm2a-3135R
• Product Overview: Acyl-coenzyme A synthetase ACSM2, mitochondrial (Acsm2)

Specification

• Description: may bind AMP; may be involved in kidney function .
• Source: E. Coli or Yeast
• Species: Rat
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 572
• Purity: >90%
• Notes: Small volumes of Acsm2a recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Acsm2a acyl-CoA synthetase medium-chain family member 2A [ Rattus norvegicus ]
• Official Symbol: Acsm2a
• Synonyms: Acsm2; KS; Acsm2; acyl-coenzyme A synthetase ACSM2, mitochondrial; butyrate--CoA ligase 2; kidney-specific protein KS; kidney-specific protein (KS); butyryl coenzyme A synthetase 2; butyryl-coenzyme A synthetase 2; middle-chain acyl-CoA synthetase 2; xenobiotic/medium-chain fatty acid:CoA ligase; acyl-CoA synthetase medium-chain family member 2
• Gene ID: 246263
• mRNA Refseq: NM_144748
• Protein Refseq: NP_653349
• UniProt ID: O70490
• Chromosome Location: 1q35
• Pathway: Amino Acid conjugation, organism-specific biosystem; Biological oxidations, organism-specific biosystem
• Function: ATP binding; butyrate-CoA ligase activity; butyrate-CoA ligase activity

Reviews

10/21/2019

So grateful for its performance!

09/14/2019

It seamlessly integrates into our experimental systems, enabling precise control and manipulation. It has greatly expanded the scope of our investigations.

08/08/2019

The functionality of this protein is outstanding.

07/02/2018

Affordable pricing without compromising on quality. Highly satisfied with the product.

05/07/2018

We are exceedingly satisfied with the quality of this protein.

Q&As

What is the role of ACSM2A in cancer metabolism?

Recent studies have suggested that ACSM2A plays a critical role in cancer metabolism by regulating the uptake and utilization of fatty acids by cancer cells.

How is ACSM2A involved in muscle function?

ACSM2A has been shown to be highly expressed in skeletal muscle and may play a role in regulating muscle function and metabolism. Studies have suggested that ACSM2A may be involved in the regulation of glucose uptake and glycogen synthesis in muscle cells.

How does ACSM2A interact with other cellular proteins and signaling pathways?

ACSM2A is known to interact with several cellular proteins and signaling pathways, including the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors and the AMP-activated protein kinase (AMPK) pathway. Further investigation is needed to fully understand the functional significance of these interactions.

What is the mechanism of ACSM2A-mediated insulin resistance?

ACSM2A-mediated insulin resistance is thought to be due to the accumulation of lipid intermediates, such as diacylglycerols and ceramides, which interfere with insulin signaling.

What is the clinical significance of ACSM2A in cancer?

ACSM2A expression has been shown to be upregulated in various types of cancer, including breast cancer and pancreatic cancer, and may serve as a potential therapeutic target for cancer treatment.

How is ACSM2A expression regulated in cancer cells?

Recent studies have suggested that ACSM2A expression is regulated by the tumor microenvironment, including hypoxia and inflammatory cytokines, in cancer cells.

What is the effect of ACSM2A inhibition on colorectal cancer cells?

Inhibition of ACSM2A activity has been shown to suppress the growth and survival of colorectal cancer cells, suggesting that ACSM2A may serve as a potential therapeutic target for colorectal cancer treatment.

What is the mechanism of action of ACSM2A in cancer cells?

The precise mechanism by which ACSM2A regulates tumor growth and survival in cancer cells is not fully understood. However, recent studies suggest that ACSM2A may modulate fatty acid metabolism and mitochondrial function to support cancer cell growth and survival.

What is the role of ACSM2A in liver steatosis?

ACSM2A has been implicated in the development of liver steatosis by promoting the uptake and accumulation of fatty acids in hepatocytes.

What is the effect of ACSM2A deficiency on energy metabolism?

ACSM2A deficiency has been shown to impair mitochondrial β-oxidation and energy metabolism, leading to metabolic dysfunction.