Recombinant Human ADAMTS2 Protein, GST-tagged

• Cat.No.: ADAMTS2-304H
• Product Overview: Human ADAMTS2 partial ORF ( NP_055059, 1112 a.a. - 1210 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 36.63 kDa
• AA Sequence: KHNDIDVFMPTLPVPTVAMEVRPSP STPLEVPLNASSTNATEDHPETNAV DEPYKIHGLEDEVQPPNLIPRRPSP YEKTRNQRIQELIDEMRKKEMLGK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 [ Homo sapiens ]
• Official Symbol: ADAMTS2
• Synonyms: ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM TS2; ADAMTS 3; hPCPNI; NPI; PCINP; procollagen I N proteinase; procollagen N endopeptidase; procollagen I N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; PNPI; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3; DKFZp686F12218
• Gene ID: 9509
• mRNA Refseq: NM_014244
• Protein Refseq: NP_055059
• MIM: 604539
• UniProt ID: O95450

Reviews

09/20/2022

The protein received was tailored to my needs, allowing me to move forward with my research.

10/15/2021

Technicians are able to provide helpful advice on product use.

03/01/2021

High protein concentrations were received and the desired experimental results were obtained.

06/30/2020

Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.

06/28/2020

The sales staff gave me good advice and allowed me to purchase products that met my research needs.

Q&As

What protein does ADAMTS2 have the highest homology with?

ADAMTS2 has high sequence homology with ADAMTS14 and ADAMTS3.

How does ADAMTS2 affect the development of myocardial hypertrophy?

Overexpression of ADAMTS2 significantly improves cardiac function and inhibits the development of myocardial hypertrophy, meaning that ADAMTS2 plays a protective role in the development of cardiac hypertrophy.

Can the tag of Recombinant Mouse Adamts2 be removed?

Yes, we are able to provide custom manufactured ADAMTS2 according to your needs.

What is the physiological function of ADAMTS2?

ADAMTS2 affects the pathogenesis of cardiovascular disease and regulates myocardial hypertrophy.

Do you offer ADAMTS2 (GST-tagged)?

We can custom produce ADAMTS2 (GST-tagged) for you.

In which tissues is ADAMTS2 mainly expressed?

ADAMTS2 is mainly expressed in connective tissues extending from the lymphatic network.

What are the effects of mutations in the ADAMTS2 gene?

Mutations in the ADAMTS2 gene cause abnormal skin development in animals and congenital connective tissue dysplasia syndrome in humans.

What substances promote the secretion of ADAMTS2?

Both cytokines TNF-α and TGF-β promote the secretion of ADAMTS2.

What diseases is ADAMTS2 currently used in research?

ADAMTS2 is widely used in cardiovascular disease research.

Will His affect my downstream experiments?

Due to the small molecular weight of the His tag, it generally does not affect the downstream application of the protein.