Recombinant Human AGTR2, GST-tagged

• Cat.No.: AGTR2-30H
• Product Overview: Recombinant Human AGTR2 (1 a.a. - 363 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ.

Specification

• Cat. No.: AGTR2-30H
• Description: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
• Source: wheat germ
• Molecular Mass: 67.6 kDa
• Sequence: MKGNSTLATTSKNITSGLHFGLVNI SGNNESTLNCSQKPSDKHLDAIPIL YYIIFVIGFLVNIVVVTLFCCQKGP KKVSSIYIFNLAVADLLLLATLPLW ATYYSYRYDWLFGPVMCKVFGSFLT LNMFASIFFITCMSVDRYQSVIYPF LSQRRNPWQASYIVPLVWCMACLSS LPTFYFRDVRTIEYLGVNACIMAFP PEKYAQWSAGIALMKNILGFIIPLI FIATCYFGIRKHLLKTNSYGKNRIT RDQVLKMAAAVVLAFIICWLPFHVL TFLDALAWMGVINSCEVIAVIDLAL PFAILLGFTNSCVNPFLYCFVGNRF QQKLRSVFRVPITWLQGKRESMSCR KSSSLREMETFVS
• Storagebuffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
• Applications: ELISA; WB
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• OfficialSymbol: AGTR2

Gene Information

• Gene Name: AGTR2 angiotensin II receptor, type 2 [ Homo sapiens ]
• Synonyms: AGTR2; angiotensin II receptor, type 2; angiotensin receptor 2; type-2 angiotensin II receptor; AT2; MRX88; angiotensin II type-2 receptor; ATGR2
• Gene ID: 186
• mRNA Refseq: NM_000686
• Protein Refseq: NP_000677
• MIM: 300034
• UniProt ID: P50052
• Chromosome Location: Xq22-q23
• Pathway: ACE Inhibitor Pathway; Class A/1 (Rhodopsin-like receptors); GPCR downstream signaling
• Function: angiotensin type II receptor activity; protein binding; receptor antagonist activity

Reviews

03/12/2022

It worked seamlessly in my experiments, yielding consistent and reliable results.

06/25/2021

The protein I purchased exceeded my expectations. It was highly pure and performed exceptionally well in my protein-protein interaction studies.

02/14/2020

I highly recommend this product. It saved me a significant amount of time and effort in my research, delivering excellent performance.

09/08/2019

It was easy to use, and the results were reproducible, giving me confidence in my data.

11/30/2018

Exceptional protein. Worth every penny.

Q&As

Are there any epigenetic modifications associated with AGTR2 expression?

Epigenetic modifications, such as DNA methylation and histone acetylation, have been implicated in regulating AGTR2 expression. Hypermethylation of the AGTR2 gene promoter has been observed in certain pathological conditions, suggesting a potential mechanism for altered AGTR2 expression and associated diseases.

How does AGTR2 impact cardiac remodeling after myocardial infarction?

AGTR2 activation can exert anti-fibrotic and anti-hypertrophic effects in the heart after myocardial infarction. AGTR2 activation promotes cardiomyocyte survival, limits adverse remodeling, and improves cardiac function, indicating its therapeutic potential in post-MI cardiac remodeling.

How does AGTR2 interact with other signaling pathways?

AGTR2 can cross-talk with other receptors and signaling pathways, such as the insulin-like growth factor 1 receptor and the Wnt/β-catenin pathway, to regulate cellular processes.

How is AGTR2 regulated at the transcriptional level?

Several transcription factors, including Sp1, AP-1, and NF-κB, can bind to the promoter region of AGTR2 and modulate its gene expression.

How is AGTR2 involved in cancer biology?

AGTR2 may have dual roles in cancer progression, acting as a tumor suppressor or a promoter depending on the specific cancer type.

What post-translational modifications are known to regulate AGTR2 activity?

Phosphorylation, ubiquitination, and glycosylation are among the post-translational modifications that can modulate AGTR2 function and signaling.

Are there any genetic polymorphisms associated with AGTR2?

Yes, certain genetic variations in AGTR2 have been linked to various diseases, including hypertension, preeclampsia, and neurological disorders.

What are the downstream signaling pathways activated by AGTR2?

AGTR2 can activate multiple signaling pathways, including phosphatases, kinases, and nitric oxide synthase.

What are the tissue-specific expression patterns of AGTR2?

AGTR2 is expressed in various tissues, including the cardiovascular system, brain, kidney, and reproductive organs.

What is the role of AGTR2 in the cardiovascular system?

AGTR2 has been implicated in cardiovascular development, blood pressure regulation, and vascular remodeling.