Recombinant Human AGTR2 protein, His&Flag-tagged

• Cat.No.: AGTR2-1058HFL
• Product Overview: Recombinant Full Length Human AGTR2 protein(NP_000677)(1-363 aa), fused with His and Flag tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His&Flag
• Form: Lyophilized from a 0.2 μm filtered solution in PBS, pH7.4 with 10% glycerin as protectant.
• Protein length: 1-363 aa
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied; 1 month, 2 to 8 °C under sterile conditions after reconstitution; 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: It is recommended to reconstitute the lyophilized powder in sterile water to 100-200 ug/ml, and further dilute with other solvents.It can be stored at 4°C for 2-7 days and should be used up as soon as possible. If not in use for a short time, please store at -20°C.

Gene Information

• Gene Name: AGTR2 angiotensin II receptor, type 2 [ Homo sapiens ]
• Official Symbol: AGTR2
• Synonyms: AGTR2; angiotensin II receptor, type 2; angiotensin receptor 2; type-2 angiotensin II receptor; AT2; MRX88; angiotensin II type-2 receptor; ATGR2
• Gene ID: 186
• mRNA Refseq: NM_000686
• Protein Refseq: NP_000677
• MIM: 300034
• UniProt ID: P50052

Reviews

03/12/2022

It worked seamlessly in my experiments, yielding consistent and reliable results.

06/25/2021

The protein I purchased exceeded my expectations. It was highly pure and performed exceptionally well in my protein-protein interaction studies.

02/14/2020

I highly recommend this product. It saved me a significant amount of time and effort in my research, delivering excellent performance.

09/08/2019

It was easy to use, and the results were reproducible, giving me confidence in my data.

11/30/2018

Exceptional protein. Worth every penny.

Q&As

Are there any epigenetic modifications associated with AGTR2 expression?

Epigenetic modifications, such as DNA methylation and histone acetylation, have been implicated in regulating AGTR2 expression. Hypermethylation of the AGTR2 gene promoter has been observed in certain pathological conditions, suggesting a potential mechanism for altered AGTR2 expression and associated diseases.

How does AGTR2 impact cardiac remodeling after myocardial infarction?

AGTR2 activation can exert anti-fibrotic and anti-hypertrophic effects in the heart after myocardial infarction. AGTR2 activation promotes cardiomyocyte survival, limits adverse remodeling, and improves cardiac function, indicating its therapeutic potential in post-MI cardiac remodeling.

How does AGTR2 interact with other signaling pathways?

AGTR2 can cross-talk with other receptors and signaling pathways, such as the insulin-like growth factor 1 receptor and the Wnt/β-catenin pathway, to regulate cellular processes.

How is AGTR2 regulated at the transcriptional level?

Several transcription factors, including Sp1, AP-1, and NF-κB, can bind to the promoter region of AGTR2 and modulate its gene expression.

How is AGTR2 involved in cancer biology?

AGTR2 may have dual roles in cancer progression, acting as a tumor suppressor or a promoter depending on the specific cancer type.

What post-translational modifications are known to regulate AGTR2 activity?

Phosphorylation, ubiquitination, and glycosylation are among the post-translational modifications that can modulate AGTR2 function and signaling.

Are there any genetic polymorphisms associated with AGTR2?

Yes, certain genetic variations in AGTR2 have been linked to various diseases, including hypertension, preeclampsia, and neurological disorders.

What are the downstream signaling pathways activated by AGTR2?

AGTR2 can activate multiple signaling pathways, including phosphatases, kinases, and nitric oxide synthase.

What are the tissue-specific expression patterns of AGTR2?

AGTR2 is expressed in various tissues, including the cardiovascular system, brain, kidney, and reproductive organs.

What is the role of AGTR2 in the cardiovascular system?

AGTR2 has been implicated in cardiovascular development, blood pressure regulation, and vascular remodeling.