Recombinant Human AHNAK Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | AHNAK-4827H |
Product Overview : | AHNAK MS Standard C13 and N15-labeled recombinant protein (NP_076965) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 15.9 kDa |
AA Sequence : | MEKEETTRELLLPNWQGSGSHGLTI AQRDDGVFVQEVTQNSPAARTGVVK EGDQIVGATIYFDNLQSGEVTQLLN TMGHHTVGLKLHRKGDRSPEPGQTW TREVFSSCSSEVFLNTPQPSALECK DQNKQKEASSQAGAVSVSTPNAGLT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | AHNAK AHNAK nucleoprotein [ Homo sapiens (human) ] |
Official Symbol : | AHNAK |
Synonyms : | AHNAK; AHNAK nucleoprotein; AHNAK nucleoprotein (desmoyokin); neuroblast differentiation-associated protein AHNAK; desmoyokin; MGC5395; AHNAK-related; AHNAKRS; |
Gene ID : | 79026 |
mRNA Refseq : | NM_024060 |
Protein Refseq : | NP_076965 |
MIM : | 103390 |
UniProt ID : | Q09666 |
Products Types
◆ Recombinant Protein | ||
AHNAK-297H | Recombinant Human AHNAK Protein, His (Fc)-Avi-tagged | +Inquiry |
Ahnak-1567M | Recombinant Mouse Ahnak Protein, Myc/DDK-tagged | +Inquiry |
AHNAK-460H | Recombinant Human AHNAK Protein, GST-tagged | +Inquiry |
AHNAK-1699H | Recombinant Human AHNAK protein, His & T7-tagged | +Inquiry |
AHNAK-461H | Recombinant Human AHNAK Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
AHNAK-8963HCL | Recombinant Human AHNAK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAHNAK has been linked to mechanosensitive signaling pathways, and its interaction with proteins involved in the cytoskeleton and membrane repair suggests a role in cellular responses to mechanical stress and stretch.
AHNAK contains several functional domains, including the AHNAK repeat domain (ARD), the ankyrin repeat domain (ANK), and the spectrin repeat domain (SRD).
AHNAK has been shown to interact with proteins involved in lipid metabolism and lipid droplet formation, suggesting a role in lipid droplet dynamics and lipid homeostasis within cells.
AHNAK interacts with actin and microtubule networks, influencing cytoskeletal dynamics and cell motility.
Yes, AHNAK can also undergo acetylation, glycosylation, and ubiquitination, which can modulate its function and stability.
AHNAK has been implicated in cancer metastasis, invasion, and cell migration, suggesting its potential role as a metastasis-associated protein in certain cancers.
Yes, AHNAK interacts with voltage-gated potassium channels (Kv1.5), regulating their localization at the plasma membrane and potentially affecting their activity.
AHNAK is recruited to the site of membrane damage, where it interacts with annexins and facilitates membrane resealing, contributing to membrane repair.
AHNAK binds to and modulates the activity of proteins involved in calcium signaling pathways, such as annexins and the plasma membrane calcium ATPase (PMCA).
AHNAK interacts with various adhesion proteins and the cytoskeleton, playing a role in stabilizing cell-cell and cell-matrix interactions and modulating cell migration.
Customer Reviews (5)
Write a reviewThe efficacy and dependability of this lab protein underscore its role as a pivotal component in our laboratory's scientific pursuits.
This protein rocks! It's made our experiments so much easier.
Prefect results demonstartion. Love it!
Seriously impressed with the results from this lab protein.
We confidently endorse this lab protein for its ability to produce dependable and replicable data, aligning with rigorous scientific standards.
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