Recombinant Human AK4, His-tagged
Cat.No. : | AK4-3448H |
Product Overview : | Recombinant human AK4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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Cat. No. : | AK4-3448H |
Description : | AK4(adenylate kinase 4) is a member of the adenylate kinase family of enzymes. This protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Inherited mutations leading to AK4 deficiencies in erythrocytes have been implicated in hemolytic anemia. |
Form : | Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl. |
Molecular Weight : | 27.4 kDa (243aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher) |
Purity : | > 90 % by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | AK4 adenylate kinase 4 [ Homo sapiens ] |
Synonyms : | AK3L1; adenylate kinase 3-like 1; AK3L1 adenylate kinase 3-like 1; AK3; AK4; MGC166959; EC 2.7.4.3; OTTHUMP00000010594; ATP-AMP transphosphorylase; GTP:AMP phosphotransferase; Adenylate kinase 3-like; adenylate kinase 3; mitochondrial adenylate kinase-3; nucleoside-triphosphate-adenylate kinase |
Gene ID : | 205 |
mRNA Refseq : | NM_001005353 |
Protein Refseq : | NP_001005353 |
MIM : | 103030 |
UniProt ID : | P27144 |
Chromosome Location : | 1p31.3 |
Pathway : | Purine metabolism |
Function : | ATP binding; GTP binding; adenylate kinase activity; nucleotide binding; transferase activity |
Products Types
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionAK3L1 protein is produced through a process called translation, where the AK3L1 gene is transcribed into messenger RNA (mRNA) molecules. These mRNA molecules are then translated by ribosomes into the corresponding AK3L1 protein.
Currently, there is limited information on the use of AK3L1 protein as a biomarker. However, studies have suggested that AK3L1 expression levels could potentially be associated with certain diseases, such as cancer, and may have diagnostic or prognostic value.
Despite its potential importance in cellular energy metabolism, AK3L1 is relatively less studied compared to other proteins. Further research is needed to fully understand its functions and mechanisms of action.
AK3L1 protein is found in various tissues and organs, including the brain, heart, liver, and skeletal muscles.
AK3L1 has been reported to interact with other proteins involved in energy metabolism pathways, such as AMPK and mitochondrial proteins. These interactions suggest the involvement of AK3L1 in cellular energy regulation.
The regulation of AK3L1 protein is not well understood. It is believed that AK3L1 expression and activity can be influenced by various factors, including cellular energy status and signaling pathways involved in metabolism.
AK3L1 has been proposed as a potential target for drug development. Inhibition of AK3L1 activity has shown promise as a therapeutic strategy for certain types of cancer.
There are currently no specific inhibitors or activators of AK3L1 that have been developed for therapeutic use. However, studies have identified certain compounds that can modulate AK3L1 expression or activity, and further research is ongoing to explore their potential applications.
AK3L1 protein has been reported to interact with several other proteins involved in mitochondrial metabolism and signaling pathways. For example, it has been shown to bind to voltage-dependent anion channels (VDACs) and hexokinase, which are both involved in regulating mitochondrial function and energy metabolism.
AK3L1 protein is primarily localized in the mitochondrial matrix, which is the central compartment of mitochondria. Its presence in this compartment suggests a role in cellular energy metabolism and ATP production.
Yes, there are genetic variations and mutations observed in the AK3L1 gene. These variations could potentially affect the function or regulation of the protein, but more research is necessary to determine their significance.
Currently, there are no known genetic diseases specifically associated with AK3L1 protein mutations. However, variations in the AK3L1 gene have been identified in genome-wide association studies (GWAS), indicating potential associations with certain diseases or traits, such as cancer susceptibility and metabolic disorders.
Research suggests that AK3L1 may be involved in certain diseases, such as cancer and neurodegenerative disorders, although more studies are needed to fully understand its role in these conditions.
AK3L1 protein is highly conserved across different species, indicating its importance and functional significance. It shows high similarity in amino acid sequence and structural features among vertebrate species.
Customer Reviews (3)
Write a reviewArmed with the AK3L1 protein and the steadfast backing of the manufacturer's technical support, I am empowered to surmount any challenges that may impede my progress.
With their profound expertise and prompt assistance, I am confident that any obstacles I encounter will be swiftly overcome.
This invaluable support propels me towards scientific advancements within my field, contributing to the collective body of knowledge.
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