AK3
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Official Full Name
adenylate kinase 3
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Overview
The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. -
Synonyms
AK3; adenylate kinase 3; adenylate kinase 3 like 1 , adenylate kinase 6 , AK3L1, AK6; GTP:AMP phosphotransferase, mitochondrial; AKL3L1; adenylate kinase 3 alpha-like 1; adenylate kinase 6, adenylate kinase 3 like 1; AK6; FIX; AK3L1; AKL3L;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AK3 Related Gene Family
AK3 involved in several pathways and played different roles in them. We selected most pathways AK3 participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Purine metabolism | PDE7A;RRM2B;NT5E;CANT1;POLD1;ADSS;PFAS;Adcy4;NT5M |
AK3 has several biochemical functions, for example, ATP binding, GTP binding, NOT adenylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK3 itself. We selected most functions AK3 had, and list some proteins which have the same functions with AK3. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ACTR1B;PDGFRB;RLN1;TK2;NME1;SIK2A;YES1;RPS6KB1B;ADRBK2 |
GTP binding | GUCY1B3;PIGC;ACSM1;DIRAS1B;GNAIA;RAB1B;RAB13;ARL1;ARF5 |
NOT adenylate kinase activity | AK4;AK3 |
nucleoside triphosphate adenylate kinase activity | AK4;AK3 |
protein binding | BNIP1;SLC16A3;SMC2;AKTIP;SRM;C11orf67;RPL23A;SKI;PDS5B |
AK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK3.
APPBP2; DAPK3; ZDHHC17; CLPP
- Q&As
- Reviews
Q&As (10)
Ask a questionAK3 protein is a homodimer, meaning it is composed of two identical subunits. Each subunit consists of about 200 amino acids and contains a nucleotide binding domain that enables AK3 to bind to ATP, ADP, and AMP. The protein structure also contains a highly conserved sequence motif found in other adenylate kinases.
Dysregulation of AK3 protein has been implicated in various diseases and conditions. Some examples include cancer, where altered AK3 expression has been observed in certain types of tumors, suggesting its involvement in cancer progression.
AK3 protein has been found to interact with other molecules within the cell. For example, it can interact with adenine nucleotides like ATP, ADP, and AMP, as well as other enzymes involved in energy metabolism. Additionally, studies have suggested potential protein-protein interactions between AK3 and other mitochondrial proteins involved in various cellular processes.
AK3 protein is primarily found in the mitochondria, which are the energy-producing organelles within cells. It is more specifically located in the mitochondrial intermembrane space.
One notable feature of AK3 protein is its ability to reversibly form disulfide bonds under oxidative conditions, which may regulate its activity and localization within the mitochondria. AK3 protein has also been implicated in protecting cells against oxidative stress and apoptosis, suggesting additional roles beyond its energy metabolism function.
There is ongoing research investigating the potential use of AK3 protein as a diagnostic or prognostic marker for certain diseases. For instance, altered expression levels of AK3 have been found in various cancers, indicating its potential as a biomarker for tumor detection or progression. However, further studies are needed to validate its clinical utility as a diagnostic or prognostic marker.
Currently, there are no specific drugs or therapeutic strategies targeting AK3 protein directly. However, understanding the role of AK3 in disease processes may help identify potential targets for drug development and therapeutic interventions in the future.
AK3 protein continues to be an active area of research. Future studies may focus on elucidating the precise molecular mechanisms underlying its role in cancer, mitochondrial disorders, and neurodegenerative diseases. Additionally, researchers may investigate potential therapeutic strategies targeting AK3 or its associated pathways as a means to treat related disorders.
Yes, there have been identified genetic variations and mutations in the AK3 gene. Some variations may alter the activity or expression levels of AK3 protein, potentially affecting its function. These genetic variations can have implications for various diseases and conditions.
While AK3 protein primarily functions in cellular energy metabolism, it can also indirectly influence signaling pathways through the regulation of AMP levels. AMP can activate the AMP-activated protein kinase (AMPK) pathway, which plays a crucial role in cellular energy sensing and regulation. Thus, by modulating AMP levels, AK3 protein may indirectly affect signaling pathways involved in metabolism, cell proliferation, and stress response.
Customer Reviews (4)
Write a reviewThe AK3 protein epitomizes unparalleled quality, positioning itself as an impeccable solution that precisely caters to my experimental requisites.
Its exceptional integrity and consistency instill utmost confidence in obtaining precise and reliable outcomes, thereby propelling my research endeavors to uncharted levels of success.
Their exemplary technical support team stands poised to address any concerns or hurdles that may arise along my experimental path.
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