Recombinant Human ALKBH1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | ALKBH1-1198H |
Product Overview : | ALKBH1 MS Standard C13 and N15-labeled recombinant protein (NP_006011) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 43.9 kDa |
AA Sequence : | MGKMAAAVGSVATLATEPGEDAFRK LFRFYRQSRPGTADLEGVIDFSAAH AARGKGPGAQKVIKSQLNVSSVSEQ NAYRAGLQPVSKWQAYGLKGYPGFI FIPNPFLPGYQWHWVKQCLKLYSQK PNVCNLDKHMSKEETQDLWEQSKEF LRYKEATKRRPRSLLEKLRWVTVGY HYNWDSKKYSADHYTPFPSDLGFLS EQVAAACGFEDFRAEAGILNYYRLD STLGIHVDRSELDHSKPLLSFSFGQ SAIFLLGGLQRDEAPTAMFMHSGDI MIMSGFSRLLNHAVPRVLPNPEGEG LPHCLEAPLPAVLPRDSMVEPCSME DWQVCASYLKTARVNMTVRQVLATD QNFPLEPIEDEKRDISTEGFCHLDD QNSEVKRARINPHSTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | ALKBH1 alkB homolog 1, histone H2A dioxygenase [ Homo sapiens (human) ] |
Official Symbol : | ALKBH1 |
Synonyms : | ALKBH1; alkB, alkylation repair homolog 1 (E. coli); alkB, alkylation repair homolog (E. coli), ALKBH; alkylated DNA repair protein alkB homolog 1; ABH; alkB; hABH; DNA lyase ABH1; alkylation repair, alkB homolog; alpha-ketoglutarate-dependent dioxygenase ABH1; ABH1; ALKBH; |
Gene ID : | 8846 |
mRNA Refseq : | NM_006020 |
Protein Refseq : | NP_006011 |
MIM : | 605345 |
UniProt ID : | Q13686 |
Products Types
◆ Recombinant Protein | ||
ALKBH1-473M | Recombinant Mouse ALKBH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Alkbh1-1599M | Recombinant Mouse Alkbh1 Protein, Myc/DDK-tagged | +Inquiry |
ALKBH1-319H | Recombinant Human ALKBH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALKBH1-2882H | Recombinant Human ALKBH1 protein, His-tagged | +Inquiry |
ALKBH1-2853Z | Recombinant Zebrafish ALKBH1 | +Inquiry |
◆ Lysates | ||
ALKBH1-8903HCL | Recombinant Human ALKBH1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (17)
Ask a questionALKBH1 can remove oxidative components and methylation markers from DNA, and is involved in DNA base repair and oxidative stress.
By studying the expression and function of ALKBH1 in liver cancer tissue, we can understand its role in the treatment of liver cancer.
ALKBH1 is mainly expressed in liver, spleen, myocardium and other tissues.
ALKBH1 plays a key role in the development and progression of gastric cancer, which may be related to the regulation of DNA repair and apoptosis.
The study on the expression level of ALKBH1 in metabolic diseases can provide new ideas for the prediction and treatment of metabolic diseases.
It can influence the function of the immune system and the occurrence of inflammatory responses, regulating cell state by removing oxidative components and methylation markers.
It has been shown to play an important role in neurological and related disorders, including mild cognitive impairment.
The expression may be regulated by various environmental factors and endogenous signals, including chemical stimulation and oxidative stress.
ALKBH1 plays a key role in DNA damage and repair, repairing 1- or 3-methyladenine in DNA.
This protein plays an important role in the occurrence and development of cardiovascular diseases, which may be related to lipid metabolism and pathway regulation.
ALKBH1 plays an important role in mammalian stem cell reprogramming, promoting stem cell proliferation and differentiation.
The mutation may affect metabolic capacity and cause liver disease, diabetes, obesity and other related diseases.
It can remove 1- or 3-methyladenine from DNA and is involved in DNA methylation repair and DNA repair processes.
The mutation may be associated with cancer, cardiovascular disease, liver disease, etc.
ALKBH1 repairs DNA damage by removing 1- or 3-methyladenine from DNA double-stranded DNA in an oxygen-dependent manner.
The expression and role of ALKBH1 in certain diseases can be comprehensively evaluated through comparative omics, immunopathology, molecular biology and other research methods, so as to provide references for disease prediction and treatment.
ALKBH1 is involved in a variety of cell signaling pathways, including NF-κB.
Customer Reviews (4)
Write a reviewCan meet the specific experimental requirements and research purposes when used in experiments.
The products are available in a wide range of specifications for different sizes and experimental designs.
When ALKBH1 was used in the experiment, clear and consistent results could be obtained, which was convenient for data analysis and interpretation.
Long half-life and is able to maintain stability and reliability during the experiment.
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