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Recombinant Human AMDHD2 protein, GST-tagged

Cat.No. : AMDHD2-518H
Product Overview : Human AMDHD2 full-length ORF ( NP_057028.2, 1 a.a. - 439 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : AMDHD2 (Amidohydrolase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include hydrolase activity and N-acetylglucosamine-6-phosphate deacetylase activity. An important paralog of this gene is ENSG00000259784.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 73.3 kDa
AA Sequence : MRGEQGAAGARVLQFTNCRILRGGK LLREDLWVRGGRILDPEKLFFEERR VADERRDCGGRILAPGFIDVQINGG FGVDFSQATEDVGSGVALVARRILS HGVTSFCPTLVTSPPEVYHKVVPQI PVKSGGPHGAGVLGLHLEGPFISRE KRGAHPEAHLRSFEADAFQDLLATY GPLDNVRIVTLAPELGRSHEVIRAL TARGICVSLGHSVADLRAAEDAVWS GATFITHLFNAMLPFHHRDPGIVGL LTSDRLPAGRCIFYGMIADGTHTNP AALRIAHRAHPQGLVLVTDAIPALG LGNGRHTLGQQEVEVDGLTAYVAGE RPDPLGPRSQPACQVAHDPPRACPL CSQGTKTLSGSIAPMDVCVRHFLQA TGCSMESALEAASLHPAQLLGLEKS KGTLDFGADADFVVLDDSLHVQATY ISGELVWQADAARQ
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AMDHD2 amidohydrolase domain containing 2 [ Homo sapiens ]
Official Symbol : AMDHD2
Synonyms : AMDHD2; amidohydrolase domain containing 2; putative N-acetylglucosamine-6-phosphate deacetylase; CGI 14; glcNAc 6-P deacetylase; amidohydrolase domain-containing protein 2; CGI-14;
Gene ID : 51005
mRNA Refseq : NM_001145815
Protein Refseq : NP_001139287
UniProt ID : Q9Y303

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What are the downstream signaling pathways or cellular processes influenced by AMDHD2 activity? 10/15/2022

AMDHD2 activity can influence downstream signaling pathways involved in cell proliferation, differentiation, or stress responses, impacting cellular metabolism, growth, or survival.

What is the subcellular localization of AMDHD2 and its significance in cellular processes? 06/04/2021

AMDHD2 exhibits a specific subcellular localization, such as in the cytoplasm or mitochondria, which is crucial for its involvement in nucleotide metabolism or other related processes.

How does AMDHD2 participate in cellular energy metabolism and the regulation of metabolic pathways? 03/16/2021

AMDHD2 contributes to cellular energy metabolism by influencing the utilization of nucleotide-derived metabolites in energy production pathways, such as mitochondrial respiration or ATP synthesis.

How does AMDHD2 contribute to nucleotide metabolism and what are the implications for cellular physiology? 08/15/2020

AMDHD2 plays a role in nucleotide metabolism, contributing to the biosynthesis, salvage, or recycling of nucleotides, which are essential for DNA synthesis, RNA transcription, and cellular signaling.

Can targeting AMDHD2 activity or expression provide potential therapeutic strategies for metabolic disorders or cancer? 01/14/2020

Modulating AMDHD2 activity or expression may hold therapeutic potential for metabolic disorders, such as nucleotide metabolism-related diseases or cancer, providing opportunities for developing targeted interventions or personalized therapies.

What is the role of AMDHD2 in DNA damage repair and genome stability maintenance? 11/23/2019

AMDHD2 is involved in DNA damage repair mechanisms, participating in the removal or repair of damaged nucleotides or DNA lesions, thus maintaining genome stability.

What are the enzymatic activities of AMDHD2 and its substrate specificity? 10/23/2019

AMDHD2 possesses enzymatic activities, such as phosphatase or hydrolase activity, and exhibits substrate specificity towards specific nucleotide derivatives or metabolic intermediates.

How does AMDHD2 deficiency or overexpression affect cellular proliferation, differentiation, or disease progression? 10/08/2019

AMDHD2 deficiency or dysregulation may lead to impaired nucleotide metabolism, DNA repair defects, altered cellular proliferation, or increased susceptibility to certain diseases, including cancer.

What are the molecular interactions of AMDHD2 with other proteins and their functional consequences? 07/10/2019

AMDHD2 interacts with other proteins involved in nucleotide metabolism, DNA repair, or cellular signaling, and these interactions modulate processes such as nucleotide synthesis, repair, or cell cycle progression.

How is AMDHD2 expression regulated under different cellular conditions or in response to metabolic cues? 04/24/2019

AMDHD2 expression is regulated at transcriptional and post-transcriptional levels, influenced by cellular signals, metabolic cues, or growth factor signaling pathways.

Customer Reviews (3)

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Reviews
12/14/2021

    Enhanced signal stability for prolonged imaging experiments.

    11/08/2019

      Low assay interference from interfering substances.

      03/04/2018

        Consistent detection of protein post-translational modifications.

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