Recombinant Mouse AMDHD2 Protein, His (Fc)-Avi-tagged

• Cat.No.: AMDHD2-504M
• Product Overview: Recombinant Mouse AMDHD2 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Mouse
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Amdhd2 amidohydrolase domain containing 2 [ Mus musculus ]
• Official Symbol: AMDHD2
• Gene ID: 245847
• mRNA Refseq: NM_172935.4
• Protein Refseq: NP_766523.2
• UniProt ID: Q8JZV7

Reviews

12/14/2021

Enhanced signal stability for prolonged imaging experiments.

11/08/2019

Low assay interference from interfering substances.

03/04/2018

Consistent detection of protein post-translational modifications.

Q&As

What are the downstream signaling pathways or cellular processes influenced by AMDHD2 activity?

AMDHD2 activity can influence downstream signaling pathways involved in cell proliferation, differentiation, or stress responses, impacting cellular metabolism, growth, or survival.

What is the subcellular localization of AMDHD2 and its significance in cellular processes?

AMDHD2 exhibits a specific subcellular localization, such as in the cytoplasm or mitochondria, which is crucial for its involvement in nucleotide metabolism or other related processes.

How does AMDHD2 participate in cellular energy metabolism and the regulation of metabolic pathways?

AMDHD2 contributes to cellular energy metabolism by influencing the utilization of nucleotide-derived metabolites in energy production pathways, such as mitochondrial respiration or ATP synthesis.

How does AMDHD2 contribute to nucleotide metabolism and what are the implications for cellular physiology?

AMDHD2 plays a role in nucleotide metabolism, contributing to the biosynthesis, salvage, or recycling of nucleotides, which are essential for DNA synthesis, RNA transcription, and cellular signaling.

Can targeting AMDHD2 activity or expression provide potential therapeutic strategies for metabolic disorders or cancer?

Modulating AMDHD2 activity or expression may hold therapeutic potential for metabolic disorders, such as nucleotide metabolism-related diseases or cancer, providing opportunities for developing targeted interventions or personalized therapies.

What is the role of AMDHD2 in DNA damage repair and genome stability maintenance?

AMDHD2 is involved in DNA damage repair mechanisms, participating in the removal or repair of damaged nucleotides or DNA lesions, thus maintaining genome stability.

What are the enzymatic activities of AMDHD2 and its substrate specificity?

AMDHD2 possesses enzymatic activities, such as phosphatase or hydrolase activity, and exhibits substrate specificity towards specific nucleotide derivatives or metabolic intermediates.

How does AMDHD2 deficiency or overexpression affect cellular proliferation, differentiation, or disease progression?

AMDHD2 deficiency or dysregulation may lead to impaired nucleotide metabolism, DNA repair defects, altered cellular proliferation, or increased susceptibility to certain diseases, including cancer.

What are the molecular interactions of AMDHD2 with other proteins and their functional consequences?

AMDHD2 interacts with other proteins involved in nucleotide metabolism, DNA repair, or cellular signaling, and these interactions modulate processes such as nucleotide synthesis, repair, or cell cycle progression.

How is AMDHD2 expression regulated under different cellular conditions or in response to metabolic cues?

AMDHD2 expression is regulated at transcriptional and post-transcriptional levels, influenced by cellular signals, metabolic cues, or growth factor signaling pathways.