Recombinant Human ANKS1A cell lysate

• Cat.No.: ANKS1A-83HCL

Specification

• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A [ Homo sapiens ]
• Official Symbol: ANKS1A
• Synonyms: ANKS1A; ankyrin repeat and sterile alpha motif domain containing 1A; ANKS1, ankyrin repeat and SAM domain containing 1 , ankyrin repeat and sterile alpha motif domain containing 1; ankyrin repeat and SAM domain-containing protein 1A; KIAA0229; Odin; ankyrin repeat and SAM domain containing 1; ANKS1; MGC42354
• Gene ID: 23294
• mRNA Refseq: NM_015245
• Protein Refseq: NP_056060
• MIM: 608994
• UniProt ID: Q92625
• Chromosome Location: 6p21.31
• Function: ephrin receptor binding

Reviews

12/31/2020

This protein has become an invaluable asset in my research, offering great versatility in its applications.

05/24/2019

the ANKS1A protein stands out for its excellent quality, exceptional technical support, and wide range of applications.

08/28/2017

It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

01/11/2016

Its robust performance has significantly accelerated my research progress and contributed to the advancement of my scientific understanding.

Q&As

Does Anks1A have any known roles in disease or pathology?

Mutations in the ANKS1A gene have been associated with neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities. These findings suggest a potential involvement of Anks1A in the pathogenesis of these conditions. However, further research is needed to understand the precise mechanisms underlying these associations.

Is Anks1A protein associated with any cellular processes other than cytoskeletal organization?

Yes, Anks1A is implicated in various cellular processes beyond cytoskeletal organization. It is believed to have roles in intracellular signaling, protein-protein interactions, calcium signaling, and potentially synaptic development and function.

What research is currently being done on Anks1A protein?

Current research on Anks1A protein focuses on understanding its role in cellular processes, its interactions with other proteins, and its potential involvement in neurodevelopmental disorders. Studies are being conducted to investigate the mechanisms of Anks1A function, its regulation, and its contribution to disease pathology.

Does Anks1A have any known functional paralogs?

Yes, Anks1A has a paralog called Anks1B (Ankyrin repeat and SAM domain-containing protein 1B) that shares high sequence similarity and similar domain architecture. Anks1B is also involved in cytoskeletal organization and protein-protein interactions, but its specific functions may differ from Anks1A.

Have any mutations in the ANKS1A gene been identified?

Yes, mutations in the ANKS1A gene have been identified in individuals with neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. These mutations can disrupt the normal function of Anks1A and suggest a potential link between ANKS1A variants and disease phenotypes.

Where is Anks1A protein located in the cell?

Anks1A is primarily localized in the cytoplasm of the cell.

What are the structural domains of Anks1A protein?

Anks1A protein contains several structural domains including multiple ankyrin repeats that are involved in protein-protein interactions, and a SAM domain (sterile alpha motif) that is implicated in protein-protein interactions and may have a role in intracellular signal transduction.

Are there any known animal models for studying Anks1A?

Yes, animal models such as knockout mice lacking the Anks1A gene have been generated to study its function. These models help researchers investigate the physiological effects of Anks1A loss and better understand its role in development and disease.

Are there any known functional domains in the Anks1A protein?

Anks1A contains several functional domains, including ankyrin repeats and SAM (sterile alpha motif) domains. Ankyrin repeats are responsible for protein-protein interactions, and SAM domains are involved in various cellular processes, including protein interactions and signal transduction.

Are there any known interactors of Anks1A protein?

Yes, several proteins have been reported to interact with Anks1A. Some of these interactors include TRPV4, p105, and Kank1/ANKS1B. These interactions suggest that Anks1A may play a role in calcium signaling, NF-κB pathway signaling, and cytoskeletal organization.