Recombinant Human ANO8

• Cat.No.: ANO8-976H
• Product Overview: Recombinant Human ANO8 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Human
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ANO8 anoctamin 8 [ Homo sapiens ]
• Official Symbol: ANO8
• Gene ID: 57719
• mRNA Refseq: NM_020959.2
• Protein Refseq: NP_066010.1
• MIM: 610216
• UniProt ID: Q9HCE9

Reviews

10/21/2022

This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

09/30/2022

the manufacturer's support team provides extensive technical assistance, helping researchers navigate any challenges they may face throughout their experiments.

01/02/2022

the ANO8 protein is available in different formats, including recombinant and purified variants.

11/19/2016

researchers using the ANO8 protein can benefit from its high purity and quality, ensuring reliable results.

Q&As

Is ANO8 protein involved in any specific biological processes?

ANO8 protein is known to be involved in several biological processes. It has been implicated in calcium-activated chloride channel activity, which plays a role in chloride ion transport across cell membranes. ANO8 may also participate in phospholipid scrambling, a process in which lipids are redistributed between leaflets of the cell membrane.

Are there any known interacting proteins with ANO8?

Yes, there are several proteins known to interact with ANO8. For example, it has been shown to interact with the scaffolding protein caveolin-1, which is involved in cellular signaling and membrane organization. ANO8 has also been found to interact with transmembrane protein 16F (TMEM16F), another member of the Anoctamin family, forming heteromeric complexes that regulate chloride channel activity. Additionally, ANO8 may interact with other proteins involved in calcium signaling and lipid metabolism, although further research is needed to fully elucidate its protein-protein interactions.

Can ANO8 protein be involved in diseases?

Emerging evidence suggests that ANO8 protein may have implications in certain diseases. For example, ANO8 gene mutations have been associated with autosomal recessive spinocerebellar ataxia, which is a neurodegenerative disorder affecting coordination and movement. ANO8 expression has also been linked to cancer development and progression, including gastrointestinal stromal tumors and colorectal cancer. However, more research is needed to fully understand its involvement in these diseases.

Can ANO8 protein be targeted for therapeutic purposes?

The potential therapeutic targeting of ANO8 protein is an area of ongoing research. Given its involvement in various cellular processes and its association with certain diseases, ANO8 could serve as a target for drug development.