Recombinant Human ARPIN lysate

• Cat.No.: ARPIN-82HCL
• Product Overview: Over-expression cells lysed in RIPA buffer and lysate supplied in SDS loading buffer

Specification

• Source: HEK 293 cells
• Species: Human
• Molecular Mass: 27442.815Da
• Recommended Usage: WB
• Storage Instruction: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Gene Information

• Gene Name: ARPIN actin-related protein 2/3 complex inhibitor [ Homo sapiens ]
• Official Symbol: ARPIN
• Synonyms: C15orf38; arpin; UPF0552 protein C15orf38; arp2/3 inhibition protein
• Gene ID: 348110
• mRNA Refseq: NM_001282380
• Protein Refseq: NP_001269309
• MIM: 615543
• UniProt ID: Q7Z6K5
• Chromosome Location: 15q26.1

Reviews

04/01/2021

This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

06/30/2020

Its exceptional performance in ELISA assays makes it a reliable tool for detecting and quantifying specific target molecules with high sensitivity and specificity.

05/12/2017

the ARPIN protein has demonstrated its efficacy in protein electron microscopy structure analysis.

Q&As

Is ARPIN evolutionarily conserved across different species?

Yes, ARPIN is conserved in various species, including mammals, birds, reptiles, and even some invertebrates. This conservation suggests that it plays an important role in regulating actin cytoskeleton dynamics throughout evolution.

What role does ARPIN play in cell migration?

ARPIN plays a crucial role in regulating cell migration. By inhibiting the Arp2/3 complex, it reduces the formation of branched actin networks at the leading edge of migrating cells. This influences the organization of the actin cytoskeleton, lamellipodia formation, and overall cell motility.

Are there any known interacting proteins of ARPIN?

Yes, several proteins have been identified as interacting partners for ARPIN. These include the Arp2/3 complex, which is the main target of ARPIN's inhibitory action, as well as other actin-binding proteins and signaling molecules involved in actin dynamics regulation. Examples of interacting proteins include WASP, WAVE, cortactin, and cofilin.

Can changes in ARPIN expression levels affect the overall actin cytoskeleton organization?

Yes, changes in ARPIN expression levels can influence actin cytoskeleton organization. Overexpression of ARPIN leads to reduced actin branching, resulting in altered actin filament architecture and cell morphology. On the other hand, decreased ARPIN expression or activity may promote excessive actin polymerization and branching, affecting cellular processes that rely on proper actin cytoskeleton dynamics.

Are there any diseases or disorders associated with ARPIN dysfunction?

While not extensively studied, dysregulation of ARPIN has been proposed to contribute to various pathological conditions. Altered expression or activity of ARPIN has been implicated in cancer metastasis, neuronal development disorders, and immune cell dysfunction, among others.

Can ARPIN be targeted for therapeutic interventions in diseases?

The potential therapeutic targeting of ARPIN is an area of active research. Modulating the activity of ARPIN could have implications for diseases such as cancer, where disruption of actin dynamics is frequently observed. However, more studies are needed to evaluate the feasibility and effectiveness of targeting ARPIN for therapeutic purposes.