Recombinant Human ARPIN Protein, His-tagged
Cat.No. : | ARPIN-151H |
Product Overview : | Recombinant Human actin related protein 2/3 complex inhibitor(ARPIN), transcript variant 1(NM_182616), with a His tag, was expressed in human cells. |
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Source : | Human Cells |
Species : | Human |
Tag : | His |
Form : | Purified protein formulated in a sterile solution of TBS buffer, pH7.30, without any preservatives. |
Molecular Mass : | 24.8 kDa |
Endotoxin : | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
Purity : | >90% by SDS-PAGE gel and Coomassie Blue staining |
Applications : | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies. |
Gene Name : | ARPIN actin related protein 2/3 complex inhibitor [ Homo sapiens ] |
Official Symbol : | ARPIN |
Synonyms : | C15orf38; C15orf38 |
Gene ID : | 348110 |
mRNA Refseq : | NM_001282380 |
Protein Refseq : | NP_001269309 |
UniProt ID : | Q7Z6K5 |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
ARPIN-82HCL | Recombinant Human ARPIN lysate | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, ARPIN is conserved in various species, including mammals, birds, reptiles, and even some invertebrates. This conservation suggests that it plays an important role in regulating actin cytoskeleton dynamics throughout evolution.
ARPIN plays a crucial role in regulating cell migration. By inhibiting the Arp2/3 complex, it reduces the formation of branched actin networks at the leading edge of migrating cells. This influences the organization of the actin cytoskeleton, lamellipodia formation, and overall cell motility.
Yes, several proteins have been identified as interacting partners for ARPIN. These include the Arp2/3 complex, which is the main target of ARPIN's inhibitory action, as well as other actin-binding proteins and signaling molecules involved in actin dynamics regulation. Examples of interacting proteins include WASP, WAVE, cortactin, and cofilin.
Yes, changes in ARPIN expression levels can influence actin cytoskeleton organization. Overexpression of ARPIN leads to reduced actin branching, resulting in altered actin filament architecture and cell morphology. On the other hand, decreased ARPIN expression or activity may promote excessive actin polymerization and branching, affecting cellular processes that rely on proper actin cytoskeleton dynamics.
While not extensively studied, dysregulation of ARPIN has been proposed to contribute to various pathological conditions. Altered expression or activity of ARPIN has been implicated in cancer metastasis, neuronal development disorders, and immune cell dysfunction, among others.
The potential therapeutic targeting of ARPIN is an area of active research. Modulating the activity of ARPIN could have implications for diseases such as cancer, where disruption of actin dynamics is frequently observed. However, more studies are needed to evaluate the feasibility and effectiveness of targeting ARPIN for therapeutic purposes.
Customer Reviews (3)
Write a reviewThis cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.
Its exceptional performance in ELISA assays makes it a reliable tool for detecting and quantifying specific target molecules with high sensitivity and specificity.
the ARPIN protein has demonstrated its efficacy in protein electron microscopy structure analysis.
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