Recombinant Human ARSD, His-tagged

• Cat.No.: ARSD-3660H
• Product Overview: Arylsulfatase D (ARSD)

Specification

• Description: The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y.
• Source: E. Coli or Yeast
• Species: Human
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 593
• Purity: >90%
• Notes: Small volumes of ARSD recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: ARSD
• Official Symbol: ARSD
• Synonyms: ARSD ; ARSD; ARSD; ASD; ASD
• Gene ID: 414
• mRNA Refseq: NM_001669.3
• Protein Refseq: NP_001660.2
• MIM: 300002
• UniProt ID: P51689
• Chromosome Location: Chromosome: X; NC_000023.10 (2822011..2847416, complement). Location: Xp22.3

Reviews

04/18/2020

The impressive performance of the ARSD protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.

11/01/2017

the ARSD protein finds extensive utility in protein electron microscopy structure analysis.

02/25/2016

Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.

Q&As

Is the ARSD protein involved in any specific biological pathways or processes?

While the precise role of ARSD in specific biological pathways is still under investigation, it is known to participate in the breakdown of sulfated molecules within lysosomes, contributing to normal cellular metabolism and recycling of molecules.

Are there any known inhibitors or activators of the ARSD protein?

Currently, there are no specific inhibitors or activators that have been developed for the ARSD protein. However, general inhibitors or activators of sulfatase enzymes might have an effect on ARSD activity.

What are the potential consequences of impaired ARSD activity?

If the activity of ARSD is impaired, it can lead to the accumulation of sulfated molecules within lysosomes. This can disrupt normal cellular processes and potentially contribute to lysosomal storage disorders or other related disorders.

Are there any known genetic disorders associated with mutations in the ARSD gene?

Currently, there are no known genetic disorders specifically associated with mutations in the ARSD gene. However, mutations in related sulfatase genes can lead to various lysosomal storage disorders, such as multiple sulfatase deficiency (MSD).

How is the ARSD protein regulated?

The regulation of ARSD protein activity is not well understood. However, like other lysosomal enzymes, its activity may be influenced by factors such as pH and post-translational modifications.