Recombinant Human ARVCF protein, GST-tagged

• Cat.No.: ARVCF-875H
• Product Overview: Human ARVCF partial ORF ( NP_001661, 863 a.a. - 962 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 36.74 kDa
• AA Sequence: LSPGGFDDSTLPLVDKSLEGEKTGS RDVIPMDALGPDGYSTVDRRERRPR GASSAGEASEKEPLKLDPSRKAPPP GPSRPAVRLVDAVGDAKPQPVDSWV
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARVCF armadillo repeat gene deleted in velocardiofacial syndrome [ Homo sapiens ]
• Official Symbol: ARVCF
• Synonyms: ARVCF; armadillo repeat gene deleted in velocardiofacial syndrome; armadillo repeat protein deleted in velo-cardio-facial syndrome; FLJ35345
• Gene ID: 421
• mRNA Refseq: NM_001670
• Protein Refseq: NP_001661
• MIM: 602269
• UniProt ID: O00192

Reviews

04/27/2022

The Arvcf Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.

06/24/2021

Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

08/29/2020

By incorporating the Arvcf Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

10/14/2016

What truly distinguishes the Arvcf Protein is the unparalleled technical support provided by the manufacturer.

04/04/2016

The Arvcf Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

Q&As

Can ARVCF regulate gene expression?

Yes, ARVCF has been shown to interact with transcription factors and co-regulate gene expression.

Is ARVCF involved in cell adhesion?

Yes, ARVCF plays a role in cell-cell adhesion processes, particularly through its interaction with N-Cadherin.

Is the expression of the ARVCF gene regulated?

Yes, the expression of the ARVCF gene is tightly regulated during development and in adult tissues.

Can alterations in ARVCF expression affect heart development?

Yes, ARVCF is important for normal heart development, and disruptions in its expression can lead to heart defects seen in VCFS.

Does ARVCF participate in the Wnt signaling pathway?

Yes, ARVCF is involved in the Wnt signaling pathway, playing a role in the transduction of Wnt signals.

Does the ARVCF protein interact with other proteins?

Yes, the ARVCF protein interacts with various proteins involved in cell adhesion and signaling, including N-Cadherin and β-catenin.

Can mutations in the ARVCF gene lead to any disorders?

Yes, mutations in the ARVCF gene have been associated with the Velo-Cardio-Facial syndrome (VCFS), a genetic disorder characterized by facial abnormalities, heart defects, and learning disabilities.

Does the ARVCF protein have any enzymatic activity?

No, the ARVCF protein does not possess any known enzymatic activity.