Recombinant Human ARX Protein, MYC/DDK-tagged

• Cat.No.: ARX-2820H
• Product Overview: Recombinant Human ARX protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Expansion of a polyalanine tract and other mutations in this gene cause X-linked mental retardation and epilepsy.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 58 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ARX aristaless related homeobox [ Homo sapiens ]
• Official Symbol: ARX
• Synonyms: CT121; EIEE1; ISSX; MRX29; MRX32; MRX33; MRX36; MRX38; MRX43; MRX54; MRX76; MRX87; MRXS1; PRTS
• Gene ID: 170302
• mRNA Refseq: NM_139058
• Protein Refseq: NP_620689
• MIM: 300382
• UniProt ID: Q96QS3

Reviews

02/26/2023

This protein has proven to be of great utility in protein electron microscopy structure analysis.

11/05/2020

I highly recommend the ARX Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

07/24/2017

The ARX Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.

Q&As

How does a mutation in the ARX gene affect brain development?

Mutations in the ARX gene disrupt normal brain development, leading to impaired neuronal migration, abnormal cortical structures, and cognitive and motor impairments.

Does the ARX protein have DNA-binding abilities?

Yes, the ARX protein contains a DNA-binding domain called the homeobox domain, allowing it to bind to specific DNA sequences and regulate gene transcription.

Is the ARX protein involved in epilepsy?

Yes, mutations in the ARX gene are associated with a higher risk of epilepsy, particularly West syndrome, a specific type of early-onset epilepsy.

Can alterations in ARX gene expression lead to intellectual disabilities?

Yes, mutations or alterations in ARX gene expression can result in intellectual disabilities, ranging from mild to severe, depending on the type of mutation and its impact on brain development.

Is the ARX protein involved in the development of other organs besides the brain?

Yes, the ARX protein also plays a role in the development of other organs, including the pancreas, testes, and skeletal muscles.

Does the ARX protein interact with other proteins?

Yes, the ARX protein interacts with various co-factors, transcriptional regulators, and chromatin remodeling proteins to regulate gene expression during brain development.

Are there any disorders associated with mutations in the ARX gene?

Yes, mutations in the ARX gene are associated with a range of neurological disorders, such as X-linked lissencephaly with abnormal genitalia (XLAG), Partington syndrome, and West syndrome.

Does the ARX protein have a role in hormone regulation?

Yes, the ARX protein is involved in the development and function of the pancreas, where it regulates the production of insulin and glucagon, hormones involved in blood sugar regulation.