Recombinant Rat ARX Protein, His (Fc)-Avi-tagged

• Cat.No.: ARX-468R
• Product Overview: Recombinant Rat ARX with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His (Fc)-Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Arx aristaless related homeobox [ Rattus norvegicus ]
• Official Symbol: ARX
• Gene ID: 317268
• mRNA Refseq: NM_001100174.1
• Protein Refseq: NP_001093644.1
• UniProt ID: A6YP92

Reviews

02/26/2023

This protein has proven to be of great utility in protein electron microscopy structure analysis.

11/05/2020

I highly recommend the ARX Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

07/24/2017

The ARX Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.

Q&As

How does a mutation in the ARX gene affect brain development?

Mutations in the ARX gene disrupt normal brain development, leading to impaired neuronal migration, abnormal cortical structures, and cognitive and motor impairments.

Does the ARX protein have DNA-binding abilities?

Yes, the ARX protein contains a DNA-binding domain called the homeobox domain, allowing it to bind to specific DNA sequences and regulate gene transcription.

Is the ARX protein involved in epilepsy?

Yes, mutations in the ARX gene are associated with a higher risk of epilepsy, particularly West syndrome, a specific type of early-onset epilepsy.

Can alterations in ARX gene expression lead to intellectual disabilities?

Yes, mutations or alterations in ARX gene expression can result in intellectual disabilities, ranging from mild to severe, depending on the type of mutation and its impact on brain development.

Is the ARX protein involved in the development of other organs besides the brain?

Yes, the ARX protein also plays a role in the development of other organs, including the pancreas, testes, and skeletal muscles.

Does the ARX protein interact with other proteins?

Yes, the ARX protein interacts with various co-factors, transcriptional regulators, and chromatin remodeling proteins to regulate gene expression during brain development.

Are there any disorders associated with mutations in the ARX gene?

Yes, mutations in the ARX gene are associated with a range of neurological disorders, such as X-linked lissencephaly with abnormal genitalia (XLAG), Partington syndrome, and West syndrome.

Does the ARX protein have a role in hormone regulation?

Yes, the ARX protein is involved in the development and function of the pancreas, where it regulates the production of insulin and glucagon, hormones involved in blood sugar regulation.