Recombinant Human ASAH1 Protein (Gln22-Trp395), N-His-tagged
Cat.No. : | ASAH1-0471H |
Product Overview : | Recombinant human ASAH1 (Gln22-Trp395) was fused with the N-His tag and was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 44.98 kDa |
Protein Length : | Gln22-Trp395 |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | 0.01M PBS, pH 7.4, 0.02% NLS |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 [ Homo sapiens (human) ] |
Official Symbol : | ASAH1 |
Synonyms : | ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase) 1; ASAH, N acylsphingosine amidohydrolase (acid ceramidase); acid ceramidase; AC; FLJ21558; PHP32; acid CDase; acylsphingosine deacylase; putative 32 kDa heart protein; PHP; ASAH; ACDase; FLJ22079; |
Gene ID : | 427 |
mRNA Refseq : | NM_001127505 |
Protein Refseq : | NP_001120977 |
MIM : | 613468 |
UniProt ID : | Q13510 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionGiven the involvement of ASAH1 in various diseases, including cancer, modulating its activity or developing ASAH1 inhibitors holds promise as potential therapeutic strategies.
Yes, alterations in ASAH1 gene expression or activity can impact cellular differentiation processes, as ceramide metabolism is crucial for normal development and tissue homeostasis.
Yes, mutations or deficiencies in the ASAH1 gene are associated with Farber disease, a rare inherited disorder characterized by the accumulation of ceramide in tissues throughout the body.
ASAH1 deficiency, as seen in Farber disease, is a genetic disorder. Prevention involves genetic counseling for at-risk individuals and prenatal testing during pregnancy.
Currently, ASAH1 deficiency is not included in routine newborn screening panels. However, advancements in testing methods may lead to its inclusion in the future.
Besides its role in ceramide metabolism, the ASAH1 protein can affect immune response, inflammation, and cellular stress responses.
Dysfunction of the ASAH1 protein impairs the breakdown of ceramide, leading to its accumulation in various tissues and disrupting cellular homeostasis.
Yes, the ASAH1 protein can modulate signaling pathways like the sphingosine-1-phosphate pathway, which influences various cellular processes such as migration, inflammation, and angiogenesis.
Customer Reviews (3)
Write a reviewSuch dedicated support makes me feel confident in my choice of using the ASAH1 protein for my experiments.
The manufacturer's commitment to excellence is truly commendable, especially when it comes to their outstanding technical support.
The ASAH1 Protein is a protein of exceptional quality that surpasses my expectations and fulfills all my experimental requirements.
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